1 to 10 of 58 literature results

• Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function.

  Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered pr…

  Authors: Cong Zhang, Ana Maria Cuervo

  Source: Nature medicine. 2008 Sep

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• Autophagy fights disease through cellular self-digestion.

  Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections …

  Authors: Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky

  Source: Nature. 2008 Feb 28

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• Autophagy regulates lipid metabolism.

  The intracellular storage and utilization of lipids are critical to maintain cellular energy homeostasis. During nutrient deprivation, cellular lipids…

  Authors: Rajat Singh, Susmita Kaushik, Yongjun Wang, Youqing Xiang, Inna Novak, Masaaki Komatsu, Keiji Tanaka, Ana Maria Cuervo, Mark J Czaja

  Source: Nature. 2009 Apr 30

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• Autophagy: in sickness and in health.

  The degradation of intracellular components in lysosomes (autophagy) has recaptured the attention of cell biologists in recent years. The main reason …

  Authors: Ana Maria Cuervo

  Source: Trends in cell biology. 2004 Feb

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• Autophagy in neurons: it is not all about food.

  The primary function of autophagy in most cell types is adaptation to starvation. Because neurons are protected from this type of stress, the physiolo…

  Authors: Ana Maria Cuervo

  Source: Trends in molecular medicine. 2006 Oct

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• Eat your heart out.

  Authors: Richard N Kitsis, Chang-Fu Peng, Ana Maria Cuervo

  Source: Nature medicine. 2007 May

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• The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane.

  Chaperone-mediated autophagy (CMA) is a selective type of autophagy by which specific cytosolic proteins are sent to lysosomes for degradation. Substr…

  Authors: Urmi Bandyopadhyay, Susmita Kaushik, Lyuba Varticovski, Ana Maria Cuervo

  Source: Molecular and cellular biology. 2008 Sep

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• Chaperone-mediated autophagy in aging and disease.

  Different mechanisms target intracellular components for their degradation into lysosomes through what is known as autophagy. In mammals, three main f…

  Authors: Ashish C Massey, Cong Zhang, Ana Maria Cuervo

  Source: Current topics in developmental biology. 2006

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• Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy.

  Three different types of autophagy-macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA)-contribute to degradation of intracellular c…

  Authors: Susmita Kaushik, Ashish C Massey, Noboru Mizushima, Ana Maria Cuervo

  Source: Molecular biology of the cell. 2008 May

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• Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing.

  Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD), and abnormal fragmentation of Tau is thought to contribute to t…

  Authors: Yipeng Wang, Marta Martinez-Vicente, Ulrike Krüger, Susmita Kaushik, Esther Wong, Eva-Maria Mandelkow, Ana Maria Cuervo, Eckhard Mandelkow

  Source: Human molecular genetics. 2009 Nov 1

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