1 to 10 of 12 literature results

• Lipid metabolism, atherogenesis and CD1-restricted antigen presentation.

  CD1 molecules are a family of major histocompatibility complex (MHC)-related glycoproteins that present lipid and glycolipid antigens to T cells. Inte…

  Authors: Amy S Major, Sebastian Joyce, Luc Van Kaer

  Source: Trends in molecular medicine. 2006 Jun

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• Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse.

  Macrophage low-density lipoprotein receptor-related protein (LRP) mediates internalization of remnant lipoproteins, and it is generally thought that b…

  Authors: Cheryl D Overton, Patricia G Yancey, Amy S Major, MacRae F Linton, Sergio Fazio

  Source: Circulation research. 2007 Mar 16

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• Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.

  BACKGROUND: Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein E (apoE) have been implicated in regulating cellular c…

  Authors: Yan Ru Su, Dwayne E Dove, Amy S Major, Alyssa H Hasty, Branden Boone, MacRae F Linton, Sergio Fazio

  Source: Circulation. 2005 May 10

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• The role of invariant natural killer T cells in lupus and atherogenesis.

  Systemic lupus erythematosus (SLE) is increasingly recognized as a risk factor for the development of premature atherosclerosis. The inflammatory proc…

  Authors: Amy S Major, Ram R Singh, Sebastian Joyce, Luc Van Kaer

  Source: Immunologic research. 2006

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• Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice.

  Cyclooxygenase (COX) 2 is expressed in atherosclerotic lesions. We have previously reported that selective inhibition of COX-2 reduces early atheroscl…

  Authors: Michael E Burleigh, Vladimir R Babaev, Patricia G Yancey, Amy S Major, Jennifer L McCaleb, John A Oates, Jason D Morrow, Sergio Fazio, Macrae F Linton

  Source: Journal of molecular and cellular cardiology. 2005 Sep

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• Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice.

  We have previously reported that the introduction of macrophage apoE into mice lacking both apoE and the LDL receptor (apoE(-)(/-)/LDLR(-)(/-)) throug…

  Authors: Sergio Fazio, Vladimir R Babaev, Michael E Burleigh, Amy S Major, Alyssa H Hasty, MacRae F Linton

  Source: Journal of lipid research. 2002 Oct

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• Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity.

  OBJECTIVE: The purpose of this study was to determine the effects of an atherogenic diet on immune function in LDLr(-/-), ApoA-I(-/-) mice. METHODS AN…

  Authors: Ashley J Wilhelm, Manal Zabalawi, Jason M Grayson, Ashley E Weant, Amy S Major, John Owen, Manish Bharadwaj, Rosemary Walzem, Lawrence Chan, Kazuhiro Oka,…

  Source: Arteriosclerosis, thrombosis, and vascular biology. 2009 Jun

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• Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus.

  Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis. The underlying mechanisms are poorly understood, and investigations…

  Authors: Aleksandar K Stanic, Charles M Stein, Adam C Morgan, Sergio Fazio, MacRae F Linton, Edward K Wakeland, Nancy J Olsen, Amy S Major

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 May 2

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• B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice.

  OBJECTIVE: Atherosclerosis is an inflammatory disease characterized by innate and adaptive immune responses. We investigated the role of B cells and a…

  Authors: Amy S Major, Sergio Fazio, MacRae F Linton

  Source: Arteriosclerosis, thrombosis, and vascular biology. 2002 Nov 1

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• Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice.

  BACKGROUND: Atherosclerosis is a disease marked by lipid accumulation and inflammation. Recently, atherosclerosis has gained recognition as an autoimm…

  Authors: Amy S Major, Michael T Wilson, Jennifer L McCaleb, Yan Ru Su, Aleksandar K Stanic, Sebastian Joyce, Luc Van Kaer, Sergio Fazio, Macrae F Linton

  Source: Arteriosclerosis, thrombosis, and vascular biology. 2004 Dec

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