1 to 10 of 15 literature results

• A hybrid vector for ligand-directed tumor targeting and molecular imaging.

  Merging tumor targeting and molecular-genetic imaging into an integrated platform is limited by lack of strategies to enable systemic yet ligand-direc…

  Authors: Amin Hajitou, Martin Trepel, Caroline E Lilley, Suren Soghomonyan, Mian M Alauddin, Frank C Marini, Bradley H Restel, Michael G Ozawa, Catherine A Moya, Roberto Rangel,…

  Source: Cell. 2006 Apr 21

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• Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands.

  We have recently identified glucose-regulated protein-78 (GRP78) as a relevant molecular target expressed in metastatic tumors by fingerprinting the c…

  Authors: Marco A Arap, Johanna Lahdenranta, Paul J Mintz, Amin Hajitou, Alvaro S Sarkis, Wadih Arap, Renata Pasqualini

  Source: Cancer cell. 2004 Sep

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• Aminopeptidase A is a functional target in angiogenic blood vessels.

  We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. To gain…

  Authors: Serena Marchiò, Johanna Lahdenranta, Reinier O Schlingemann, Donatella Valdembri, Pieter Wesseling, Marco A Arap, Amin Hajitou, Michael G Ozawa, Martin Trepel, Ricardo J Giordano,…

  Source: Cancer cell. 2004 Feb

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• Vascular targeting: recent advances and therapeutic perspectives.

  The ability to deliver therapeutics site-specifically in vivo -- remains a major challenge for the treatment of malignant, inflammatory, cardiovascula…

  Authors: Amin Hajitou, Renata Pasqualini, Wadih Arap

  Source: Trends in cardiovascular medicine. 2006 Apr

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• In vivo detection of gold-imidazole self-assembly complexes: NIR-SERS signal reporters.

  Here we report in vitro and in vivo detection of self-assembled Au-imidazole by using near-infrared surface-enhanced Raman scattering (NIR-SERS). In v…

  Authors: Glauco R Souza, Carly S Levin, Amin Hajitou, Renata Pasqualini, Wadih Arap, J Houston Miller

  Source: Analytical chemistry. 2006 Sep 1

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• A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer.

  Suicide gene transfer is the most commonly used cytotoxic approach in cancer gene therapy; however, a successful suicide gene therapy depends on the g…

  Authors: Martin Trepel, Charlotte A Stoneham, Hariklia Eleftherohorinou, Nicholas D Mazarakis, Renata Pasqualini, Wadih Arap, Amin Hajitou

  Source: Molecular cancer therapeutics. 2009 Aug

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• Tumor vasculature-targeted delivery of tumor necrosis factor-alpha.

  BACKGROUND: Recently, considerable efforts have been directed toward antivascular therapy as a new modality to treat human cancers. However, targeting…

  Authors: Anita Tandle, Engy Hanna, Dominique Lorang, Amin Hajitou, Catherine A Moya, Renata Pasqualini, Wadih Arap, Asha Adem, Elizabeth Starker, Stephen Hewitt,…

  Source: Cancer. 2009 Jan 1

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• Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature.

  BACKGROUND: Under the direction and sponsorship of the National Cancer Institute, we report on the first pre-clinical trial of the Comparative Oncolog…

  Authors: Melissa C Paoloni, Anita Tandle, Christina Mazcko, Engy Hanna, Stefan Kachala, Amy Leblanc, Shelley Newman, David Vail, Carolyn Henry, Douglas Thamm,…

  Source: PloS one. 2009

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• Design and construction of targeted AAVP vectors for mammalian cell transduction.

  Bacteriophage (phage) evolved as bacterial viruses, but can be adapted to transduce mammalian cells through ligand-directed targeting to a specific re…

  Authors: Amin Hajitou, Roberto Rangel, Martin Trepel, Suren Soghomonyan, Juri G Gelovani, Mian M Alauddin, Renata Pasqualini, Wadih Arap

  Source: Nature protocols. 2007

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• Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU.

  Non-invasive imaging of transgene expression requires the appropriate combination of a reporter gene and a reporter probe. [18F]FEAU positron emission…

  Authors: Suren Soghomonyan, Amin Hajitou, Roberto Rangel, Martin Trepel, Renata Pasqualini, Wadih Arap, Juri G Gelovani, Mian M Alauddin

  Source: Nature protocols. 2007

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