1 to 10 of 19 literature results

• Reconstructing Indian population history.

  India has been underrepresented in genome-wide surveys of human variation. We analyse 25 diverse groups in India to provide strong evidence for two an…

  Authors: David Reich, Kumarasamy Thangaraj, Nick Patterson, Alkes L Price, Lalji Singh

  Source: Nature. 2009 Sep 24

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• Principal components analysis corrects for stratification in genome-wide association studies.

  Population stratification--allele frequency differences between cases and controls due to systematic ancestry differences-can cause spurious associati…

  Authors: Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich

  Source: Nature genetics. 2006 Aug

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• A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia.

  Heart failure is a leading cause of mortality in South Asians. However, its genetic etiology remains largely unknown. Cardiomyopathies due to sarcomer…

  Authors: Perundurai S Dhandapany, Sakthivel Sadayappan, Yali Xue, Gareth T Powell, Deepa Selvi Rani, Prathiba Nallari, Taranjit Singh Rai, Madhu Khullar, Pedro Soares, Ajay Bahl,…

  Source: Nature genetics. 2009 Feb

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• Principal component analysis of genetic data.

  Authors: David Reich, Alkes L Price, Nick Patterson

  Source: Nature genetics. 2008 May

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• Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

  To identify susceptibility alleles associated with rheumatoid arthritis, we genotyped 397 individuals with rheumatoid arthritis for 116,204 SNPs and c…

  Authors: Robert M Plenge, Chris Cotsapas, Leela Davies, Alkes L Price, Paul I W de Bakker, Julian Maller, Itsik Pe'er, Noel P Burtt, Brendan Blumenstiel, Matt DeFelice,…

  Source: Nature genetics. 2007 Dec

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• Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants.

  Statistical power to detect disease variants can be increased by weighting candidates by their evidence of natural selection. To demonstrate that this…

  Authors: George Ayodo, Alkes L Price, Alon Keinan, Arthur Ajwang, Michael F Otieno, Alloys S S Orago, Nick Patterson, David Reich

  Source: American journal of human genetics. 2007 Aug

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• Orthologous repeats and mammalian phylogenetic inference.

  Determining phylogenetic relationships between species is a difficult problem, and many phylogenetic relationships remain unresolved, even among euthe…

  Authors: Ali Bashir, Chun Ye, Alkes L Price, Vineet Bafna

  Source: Genome research. 2005 Jul

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• Whole-genome analysis of Alu repeat elements reveals complex evolutionary history.

  Alu repeats are the most abundant family of repeats in the human genome, with over 1 million copies comprising 10% of the genome. They have been impli…

  Authors: Alkes L Price, Eleazar Eskin, Pavel A Pevzner

  Source: Genome research. 2004 Nov

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• A genomewide admixture map for Latino populations.

  Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven success…

  Authors: Alkes L Price, Nick Patterson, Fuli Yu, David R Cox, Alicja Waliszewska, Gavin J McDonald, Arti Tandon, Christine Schirmer, Julie Neubauer, Gabriel Bedoya,…

  Source: American journal of human genetics. 2007 Jun

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• Long-range LD can confound genome scans in admixed populations.

  Authors: Alkes L Price, Michael E Weale, Nick Patterson, Simon R Myers, Anna C Need, Kevin V Shianna, Dongliang Ge, Jerome I Rotter, Esther Torres, Kent D Taylor,…

  Source: American journal of human genetics. 2008 Jul

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