10 literature results

• Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.

  Integrins are the major adhesion receptors of leukocytes and platelets. Beta1 and beta2 integrin function on leukocytes is crucial for a successful im…

  Authors: Lena Svensson, Kimberley Howarth, Alison McDowall, Irene Patzak, Rachel Evans, Siegfried Ussar, Markus Moser, Ayse Metin, Mike Fried, Ian Tomlinson,…

  Source: Nature medicine. 2009 Mar

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• Integrins in immunity.

  A successful immune response depends on the capacity of immune cells to travel from one location in the body to another--these cells are rapid migrato…

  Authors: Rachel Evans, Irene Patzak, Lena Svensson, Katia De Filippo, Kristian Jones, Alison McDowall, Nancy Hogg

  Source: Journal of cell science. 2009 Jan 15

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• Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response.

  Shedding of adhesion molecules has been described for members of the selectin and immunoglobulin superfamilies, but integrins are not known to be shed…

  Authors: Betsy J Evans, Alison McDowall, Peter C Taylor, Nancy Hogg, Dorian O Haskard, R Clive Landis

  Source: Blood. 2006 May 1

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• The role of the integrin LFA-1 in T-lymphocyte migration.

  A successful immune response depends on the migration of lymphocytes into lymph nodes or inflamed tissues where they make contact with antigen-present…

  Authors: Andrew Smith, Paula Stanley, Kristian Jones, Lena Svensson, Alison McDowall, Nancy Hogg

  Source: Immunological reviews. 2007 Aug

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• CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.

  CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell ty…

  Authors: David P Inwald, Alison McDowall, Mark J Peters, Robin E Callard, Nigel J Klein

  Source: Circulation research. 2003 May 16

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• T-cell integrins: more than just sticking points.

  T cells use integrins in essentially all of their functions. They use integrins to migrate in and out of lymph nodes and, following infection, to migr…

  Authors: Nancy Hogg, Melanie Laschinger, Katherine Giles, Alison McDowall

  Source: Journal of cell science. 2003 Dec 1

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• Mechanisms contributing to the activity of integrins on leukocytes.

  Understanding how the integrins on leukocytes operate is important because these receptors control the activity of leukocytes in all phases of their l…

  Authors: Nancy Hogg, Robert Henderson, Birgit Leitinger, Alison McDowall, Joanna Porter, Paula Stanley

  Source: Immunological reviews. 2002 Aug

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• How T cells use LFA-1 to attach and migrate.

  The T lymphocyte (or T cell) has classically been perceived to be a passive circular cell attaching to other cells or fibrils of the extracellular mat…

  Authors: Nancy Hogg, Andrew Smith, Alison McDowall, Katherine Giles, Paula Stanley, Melanie Laschinger, Robert Henderson

  Source: Immunology letters. 2004 Mar 29

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• Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.

  T lymphocytes use LFA-1 to migrate into lymph nodes and inflammatory sites. To investigate the mechanisms regulating this migration, we utilize mAbs s…

  Authors: Paula Stanley, Andrew Smith, Alison McDowall, Alastair Nicol, Daniel Zicha, Nancy Hogg

  Source: The EMBO journal. 2008 Jan 9

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• A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.

  The adhesion receptors known as integrins perform key functions for hematopoietic cells. The platelet integrin alphaIIbbeta3 is critical in hemostasis…

  Authors: Alison McDowall, David Inwald, Birgit Leitinger, Alison Jones, Ri Liesner, Nigel Klein, Nancy Hogg

  Source: The Journal of clinical investigation. 2003 Jan

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