1 to 10 of 26 literature results

• Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.

  Previous proteomic and transcriptional analyses of multiple sclerosis lesions revealed modulation of the renin-angiotensin and the opposing kallikrein…

  Authors: Ulf Schulze-Topphoff, Alexandre Prat, Timour Prozorovski, Volker Siffrin, Magdalena Paterka, Josephine Herz, Ivo Bendix, Igal Ifergan, Ines Schadock, Marcelo A Mori,…

  Source: Nature medicine. 2009 Jul

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• Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.

  T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22…

  Authors: Hania Kebir, Katharina Kreymborg, Igal Ifergan, Aurore Dodelet-Devillers, Romain Cayrol, Monique Bernard, Fabrizio Giuliani, Nathalie Arbour, Burkhard Becher, Alexandre Prat

  Source: Nature medicine. 2007 Oct

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• Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system.

  Adhesion molecules of the immunoglobulin superfamily are crucial effectors of leukocyte trafficking into the central nervous system. Using a lipid raf…

  Authors: Romain Cayrol, Karolina Wosik, Jennifer L Berard, Aurore Dodelet-Devillers, Igal Ifergan, Hania Kebir, Arsalan S Haqqani, Katharina Kreymborg, Sebastian Krug, Robert Moumdjian,…

  Source: Nature immunology. 2008 Feb

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• Preferential recruitment of interferon-gamma-expressing T H 17 cells in multiple sclerosis.

  OBJECTIVE: There is substantial evidence supporting the role of interferon (IFN)-gamma-producing T helper (T(H)) 1 and interleukin (IL)-17-expressing …

  Authors: Hania Kebir, Igal Ifergan, Jorge Ivan Alvarez, Monique Bernard, Josée Poirier, Nathalie Arbour, Pierre Duquette, Alexandre Prat

  Source: Annals of neurology. 2009 Sep

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• Th1 polarization of CD4+ T cells by Toll-like receptor 3-activated human microglia.

  ABSTRACT: Toll-like receptors (TLRs) are expressed by human microglia and translate environmental cues into distinct activation programs. We addressed…

  Authors: Carolyn S Jack, Nathalie Arbour, Manon Blain, Ute-Christiane Meier, Alexandre Prat, Jack P Antel

  Source: Journal of neuropathology and experimental neurology. 2007 Sep

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• Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis.

  OBJECTIVE: Dysregulation of the blood-brain barrier (BBB) and transendothelial migration of immune cells are among the earliest central nervous system…

  Authors: Igal Ifergan, Karolina Wosik, Romain Cayrol, Hania Kébir, Chantale Auger, Monique Bernard, Alain Bouthillier, Robert Moumdjian, Pierre Duquette, Alexandre Prat

  Source: Annals of neurology. 2006 Jul

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• Pathogenesis of multiple sclerosis.

  PURPOSE OF REVIEW: The aim of this article is to describe recent observations regarding the basis for the initiation and disease evolution of multiple…

  Authors: Alexandre Prat, Jack Antel

  Source: Current opinion in neurology. 2005 Jun

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• Death receptor expression and function at the human blood brain barrier.

  The blood brain barrier (BBB) is composed of specialized endothelial cells tightly anastomosed to one another and surrounded by a thick extracellular …

  Authors: Karolina Wosik, Katarzyna Biernacki, Marie-Pierre Khouzam, Alexandre Prat

  Source: Journal of the neurological sciences. 2007 Aug 15

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• Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis.

  BACKGROUND: Interferon beta therapy has been shown to reduce the rate of clinical relapse and the frequency of magnetic resonance imaging-defined T2- …

  Authors: Katarzyna Biernacki, Jack P Antel, Manon Blain, Sridar Narayanan, Douglas L Arnold, Alexandre Prat

  Source: Archives of neurology. 2005 Apr

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• Regulation of cellular and molecular trafficking across human brain endothelial cells by Th1- and Th2-polarized lymphocytes.

  We used adult human brain-derived endothelial cells (HBECs) to model migration of peripheral blood lymphocytes across the blood brain barrier (BBB) as…

  Authors: Katarzyna Biernacki, Alexandre Prat, Manon Blain, Jack P Antel

  Source: Journal of neuropathology and experimental neurology. 2004 Mar

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