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1 to 10 of 26 literature results
Previous proteomic and transcriptional analyses of multiple sclerosis lesions revealed modulation of the renin-angiotensin and the opposing kallikrein…
Authors: Ulf Schulze-Topphoff, Alexandre Prat, Timour Prozorovski, Volker Siffrin, Magdalena Paterka, Josephine Herz, Ivo Bendix, Igal Ifergan, Ines Schadock, Marcelo A Mori,…
Source: Nature medicine. 2009 Jul
View Full TextT(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22…
Authors: Hania Kebir, Katharina Kreymborg, Igal Ifergan, Aurore Dodelet-Devillers, Romain Cayrol, Monique Bernard, Fabrizio Giuliani, Nathalie Arbour, Burkhard Becher, Alexandre Prat
Source: Nature medicine. 2007 Oct
View Full TextAdhesion molecules of the immunoglobulin superfamily are crucial effectors of leukocyte trafficking into the central nervous system. Using a lipid raf…
Authors: Romain Cayrol, Karolina Wosik, Jennifer L Berard, Aurore Dodelet-Devillers, Igal Ifergan, Hania Kebir, Arsalan S Haqqani, Katharina Kreymborg, Sebastian Krug, Robert Moumdjian,…
Source: Nature immunology. 2008 Feb
View Full TextOBJECTIVE: There is substantial evidence supporting the role of interferon (IFN)-gamma-producing T helper (T(H)) 1 and interleukin (IL)-17-expressing …
Authors: Hania Kebir, Igal Ifergan, Jorge Ivan Alvarez, Monique Bernard, Josée Poirier, Nathalie Arbour, Pierre Duquette, Alexandre Prat
Source: Annals of neurology. 2009 Sep
View Full TextABSTRACT: Toll-like receptors (TLRs) are expressed by human microglia and translate environmental cues into distinct activation programs. We addressed…
Authors: Carolyn S Jack, Nathalie Arbour, Manon Blain, Ute-Christiane Meier, Alexandre Prat, Jack P Antel
Source: Journal of neuropathology and experimental neurology. 2007 Sep
View Full TextOBJECTIVE: Dysregulation of the blood-brain barrier (BBB) and transendothelial migration of immune cells are among the earliest central nervous system…
Authors: Igal Ifergan, Karolina Wosik, Romain Cayrol, Hania Kébir, Chantale Auger, Monique Bernard, Alain Bouthillier, Robert Moumdjian, Pierre Duquette, Alexandre Prat
Source: Annals of neurology. 2006 Jul
View Full TextPURPOSE OF REVIEW: The aim of this article is to describe recent observations regarding the basis for the initiation and disease evolution of multiple…
Authors: Alexandre Prat, Jack Antel
Source: Current opinion in neurology. 2005 Jun
View Full TextThe blood brain barrier (BBB) is composed of specialized endothelial cells tightly anastomosed to one another and surrounded by a thick extracellular …
Authors: Karolina Wosik, Katarzyna Biernacki, Marie-Pierre Khouzam, Alexandre Prat
Source: Journal of the neurological sciences. 2007 Aug 15
View Full TextBACKGROUND: Interferon beta therapy has been shown to reduce the rate of clinical relapse and the frequency of magnetic resonance imaging-defined T2- …
Authors: Katarzyna Biernacki, Jack P Antel, Manon Blain, Sridar Narayanan, Douglas L Arnold, Alexandre Prat
Source: Archives of neurology. 2005 Apr
View Full TextWe used adult human brain-derived endothelial cells (HBECs) to model migration of peripheral blood lymphocytes across the blood brain barrier (BBB) as…
Authors: Katarzyna Biernacki, Alexandre Prat, Manon Blain, Jack P Antel
Source: Journal of neuropathology and experimental neurology. 2004 Mar
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