1 to 10 of 12 literature results

• Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

  Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-alpha catalytic subunit (encoded by PIK3CA). They ar…

  Authors: Jeffrey A Engelman, Liang Chen, Xiaohong Tan, Katherine Crosby, Alexander R Guimaraes, Rabi Upadhyay, Michel Maira, Kate McNamara, Samanthi A Perera, Youngchul Song,…

  Source: Nature medicine. 2008 Dec

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• The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.

  Phosphoinositide 3-kinase (PI3K) plays a critical role in tumorigenesis, and the PI3K p85 regulatory subunit exerts both positive and negative effects…

  Authors: Cullen M Taniguchi, Jonathon Winnay, Tatsuya Kondo, Roderick T Bronson, Alexander R Guimaraes, José O Alemán, Ji Luo, Gregory Stephanopoulos, Ralph Weissleder, Lewis C Cantley,…

  Source: Cancer research. 2010 Jul 1

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• Implantable diagnostic device for cancer monitoring.

  Biopsies provide required information to diagnose cancer but, because of their invasiveness, they are difficult to use for managing cancer therapy. Th…

  Authors: Karen D Daniel, Grace Y Kim, Christophoros C Vassiliou, Marilyn Galindo, Alexander R Guimaraes, Ralph Weissleder, Al Charest, Robert Langer, Michael J Cima

  Source: Biosensors & bioelectronics. 2009 Jul 15

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• Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancer.

  OBJECTIVE: To assess lymphotrophic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients wit…

  Authors: Alexander R Guimaraes, Shahin Tabatabei, Douglas Dahl, W Scott McDougal, Ralph Weissleder, Mukesh G Harisinghani

  Source: Urology. 2008 Apr

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• Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model.

  OBJECTIVES: The sonic hedgehog (Shh) pathway has an established role in pancreatic cancer (pancreatic adenocarcinoma [PDAC]). We tested whether magnet…

  Authors: Alexander R Guimaraes, Elena Rakhlin, Ralph Weissleder, Sarah P Thayer

  Source: Pancreas. 2008 Nov

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• A case of an asymptomatic hypoechoic testicular mass in the setting of contralateral orchitis.

  BACKGROUND: A 28-year-old heterosexual man presented to an emergency department with a 2-day history of left testicular pain and swelling that began a…

  Authors: Richard E A Morris, Alexander R Guimaraes

  Source: Nature clinical practice. Urology. 2009 Feb

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• MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition.

  PURPOSE: To study the effect of mammalian target of rapamycin (mTOR) inhibition on angiogenesis with magnetic resonance imaging (MRI) using magnetic i…

  Authors: Alexander R Guimaraes, Robert Ross, Jose L Figuereido, Peter Waterman, Ralph Weissleder

  Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2010 Jun 18

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• Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy.

  Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotro…

  Authors: Robert W Ross, Anthony L Zietman, Wanling Xie, John J Coen, Douglas M Dahl, William U Shipley, Donald S Kaufman, Tina Islam, Alexander R Guimaraes, Ralph Weissleder,…

  Source: Clinical imaging. 2009 Jul-Aug

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• Utility of a new bolus-injectable nanoparticle for clinical cancer staging.

  BACKGROUND: In this study, we report on the use of a new, bolus-injectable, carboxymethyl dextran-based magnetic nanoparticle (MNP), ferumoxytol, to i…

  Authors: Mukesh Harisinghani, Robert W Ross, Alexander R Guimaraes, Ralph Weissleder

  Source: Neoplasia (New York, N.Y.). 2007 Dec

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• Imaging primary lung cancers in mice to study radiation biology.

  PURPOSE: To image a genetically engineered mouse model of non-small-cell lung cancer with micro-computed tomography (micro-CT) to measure tumor respon…

  Authors: David G Kirsch, Jan Grimm, Alexander R Guimaraes, Gregory R Wojtkiewicz, Bradford A Perez, Philip M Santiago, Nikolas K Anthony, Thomas Forbes, Karen Doppke, Ralph Weissleder,…

  Source: International journal of radiation oncology, biology, physics. 2010 Mar 15

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