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1 to 10 of 12 literature results
Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-alpha catalytic subunit (encoded by PIK3CA). They ar…
Authors: Jeffrey A Engelman, Liang Chen, Xiaohong Tan, Katherine Crosby, Alexander R Guimaraes, Rabi Upadhyay, Michel Maira, Kate McNamara, Samanthi A Perera, Youngchul Song,…
Source: Nature medicine. 2008 Dec
View Free Full TextPhosphoinositide 3-kinase (PI3K) plays a critical role in tumorigenesis, and the PI3K p85 regulatory subunit exerts both positive and negative effects…
Authors: Cullen M Taniguchi, Jonathon Winnay, Tatsuya Kondo, Roderick T Bronson, Alexander R Guimaraes, José O Alemán, Ji Luo, Gregory Stephanopoulos, Ralph Weissleder, Lewis C Cantley,…
Source: Cancer research. 2010 Jul 1
View Full TextBiopsies provide required information to diagnose cancer but, because of their invasiveness, they are difficult to use for managing cancer therapy. Th…
Authors: Karen D Daniel, Grace Y Kim, Christophoros C Vassiliou, Marilyn Galindo, Alexander R Guimaraes, Ralph Weissleder, Al Charest, Robert Langer, Michael J Cima
Source: Biosensors & bioelectronics. 2009 Jul 15
View Free Full TextOBJECTIVE: To assess lymphotrophic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients wit…
Authors: Alexander R Guimaraes, Shahin Tabatabei, Douglas Dahl, W Scott McDougal, Ralph Weissleder, Mukesh G Harisinghani
Source: Urology. 2008 Apr
View Full TextOBJECTIVES: The sonic hedgehog (Shh) pathway has an established role in pancreatic cancer (pancreatic adenocarcinoma [PDAC]). We tested whether magnet…
Authors: Alexander R Guimaraes, Elena Rakhlin, Ralph Weissleder, Sarah P Thayer
Source: Pancreas. 2008 Nov
View Full TextBACKGROUND: A 28-year-old heterosexual man presented to an emergency department with a 2-day history of left testicular pain and swelling that began a…
Authors: Richard E A Morris, Alexander R Guimaraes
Source: Nature clinical practice. Urology. 2009 Feb
View Full TextPURPOSE: To study the effect of mammalian target of rapamycin (mTOR) inhibition on angiogenesis with magnetic resonance imaging (MRI) using magnetic i…
Authors: Alexander R Guimaraes, Robert Ross, Jose L Figuereido, Peter Waterman, Ralph Weissleder
Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2010 Jun 18
View Full TextTwenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotro…
Authors: Robert W Ross, Anthony L Zietman, Wanling Xie, John J Coen, Douglas M Dahl, William U Shipley, Donald S Kaufman, Tina Islam, Alexander R Guimaraes, Ralph Weissleder,…
Source: Clinical imaging. 2009 Jul-Aug
View Full TextBACKGROUND: In this study, we report on the use of a new, bolus-injectable, carboxymethyl dextran-based magnetic nanoparticle (MNP), ferumoxytol, to i…
Authors: Mukesh Harisinghani, Robert W Ross, Alexander R Guimaraes, Ralph Weissleder
Source: Neoplasia (New York, N.Y.). 2007 Dec
View Free Full TextPURPOSE: To image a genetically engineered mouse model of non-small-cell lung cancer with micro-computed tomography (micro-CT) to measure tumor respon…
Authors: David G Kirsch, Jan Grimm, Alexander R Guimaraes, Gregory R Wojtkiewicz, Bradford A Perez, Philip M Santiago, Nikolas K Anthony, Thomas Forbes, Karen Doppke, Ralph Weissleder,…
Source: International journal of radiation oncology, biology, physics. 2010 Mar 15
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