1 to 10 of 23 literature results

• Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo.

  Growth-kill dynamics were characterized in vitro, and the parameter estimates were used to simulate bacterial growth and kill in vivo using both mouse…

  Authors: Johan W Mouton, Nieko Punt, Alexander A Vinks

  Source: Antimicrobial agents and chemotherapy. 2007 Sep

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• Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation.

  Aztreonam (AZM) is a monobactam antibiotic with a high level of activity against gram-negative micro-organisms, including Pseudomonas aeruginosa. We e…

  Authors: Alexander A Vinks, Ronald N van Rossem, Ron A A Mathôt, Harry G M Heijerman, Johan W Mouton

  Source: Antimicrobial agents and chemotherapy. 2007 Sep

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• Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration.

  BACKGROUND: The minimum inhibitory concentration (MIC) is the in vitro reference value to describe the activity of an antibacterial against micro-orga…

  Authors: Johan W Mouton, Alexander A Vinks

  Source: Clinical pharmacokinetics. 2005

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• Pharmacokinetics and Pharmacodynamics of Mycophenolic Acid and Their Relation to Response to Therapy of Childhood-Onset Systemic Lupus Erythematosus.

  OBJECTIVES: Mycophenolic acid (MPA) is the active form of mycophenolate mofetil (MMF), which is currently used off-label as immunosuppressive therapy …

  Authors: Anna Carmela P Sagcal-Gironella, Tsuyoshi Fukuda, Kristina Wiers, Shareen Cox, Shannen Nelson, Blair Dina, Catherine M T Sherwin, Marisa S Klein-Gitelman, Alexander A Vinks, Hermine I Brunner

  Source: Seminars in arthritis and rheumatism. 2010 Jul 22

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• Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients.

  OBJECTIVE: The aim of this study was to examine the association between the CYP2D6 and CYP2C19 genotype-predicted combined phenotypes and short-term m…

  Authors: Cynthia A Prows, Todd G Nick, Shannon N Saldaña, Sanjeev Pathak, Chunyan Liu, Kejian Zhang, Zachary S Daniels, Alexander A Vinks, Tracy A Glauser

  Source: Journal of child and adolescent psychopharmacology. 2009 Aug

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• Monitoring of inosine monophosphate dehydrogenase activity as a biomarker for mycophenolic acid effect: potential clinical implications.

  Mycophenolic acid (MPA) is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) and, in combination with other immunosuppressive drug…

  Authors: Nicole A Weimert, Maurits Derotte, Rita R Alloway, E Steve Woodle, Alexander A Vinks

  Source: Therapeutic drug monitoring. 2007 Apr

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• A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit.

  BACKGROUND: Over the past decades, the relationship between the pharmacokinetic (PK) properties of antibiotics, MICs, and clinical effects has been in…

  Authors: Johan W Mouton, Nieko Punt, Alexander A Vinks

  Source: Clinical therapeutics. 2005 Jun

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• Development of a population pharmacokinetic model for carbamazepine based on sparse therapeutic monitoring data from pediatric patients with epilepsy.

  BACKGROUND: Population models can be important extensions of therapeutic drug monitoring (TDM), as they allow estimation of individual pharmacokinetic…

  Authors: Kristin Cecilie Carlsson, Nils Ove Hoem, Tracy Glauser, Alexander A Vinks

  Source: Clinical therapeutics. 2005 May

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• Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study.

  BACKGROUND: Promising data regarding the safety and efficacy of gastric bypass surgery (GBS) as an option to address obesity in the transplant populat…

  Authors: Christin C Rogers, Rita R Alloway, J Wesley Alexander, Michael Cardi, Jennifer Trofe, Alexander A Vinks

  Source: Clinical transplantation. 2008 May-Jun

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• Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders.

  BACKGROUND: Risperidone is a second-generation antipsychotic agent widely used in the treatment of schizophrenia and other psychotic disorders in adul…

  Authors: Michael G Aman, Alexander A Vinks, Bart Remmerie, Erik Mannaert, Yaser Ramadan, Jessica Masty, Ronald L Lindsay, Krista Malone

  Source: Clinical therapeutics. 2007 Jul

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