1 to 3 of 3 literature results

• PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.

  Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents and to restrict autoimmune responses against self antigen…

  Authors: Lata Mukundan, Justin I Odegaard, Christine R Morel, Jose E Heredia, Julia W Mwangi, Roberto R Ricardo-Gonzalez, Y P Sharon Goh, Alex Red Eagle, Shannon E Dunn, Jennifer U H Awakuni,…

  Source: Nature medicine. 2009 Nov

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• Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.

  Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely associated with a state of low-grade inflammation. In adipose…

  Authors: Justin I Odegaard, Roberto R Ricardo-Gonzalez, Matthew H Goforth, Christine R Morel, Vidya Subramanian, Lata Mukundan, Alex Red Eagle, Divya Vats, Frank Brombacher, Anthony W Ferrante,…

  Source: Nature. 2007 Jun 28

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• Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

  Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activa…

  Authors: Justin I Odegaard, Roberto R Ricardo-Gonzalez, Alex Red Eagle, Divya Vats, Christine R Morel, Matthew H Goforth, Vidya Subramanian, Lata Mukundan, Anthony W Ferrante, Ajay Chawla

  Source: Cell metabolism. 2008 Jun

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