1 to 3 of 3 literature results

• Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

  Activated oncogenes induce compensatory tumour-suppressive responses, such as cellular senescence or apoptosis, but the signals determining the main o…

  Authors: Stefano Campaner, Mirko Doni, Per Hydbring, Alessandro Verrecchia, Lucia Bianchi, Domenico Sardella, Thomas Schleker, Daniele Perna, Susanna Tronnersjö, Matilde Murga,…

  Source: Nature cell biology. 2010 Jan

  View Full Text

• Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.

  The acetyl-transferase Tip60 might influence tumorigenesis in multiple ways. First, Tip60 is a co-regulator of transcription factors that either promo…

  Authors: Chiara Gorrini, Massimo Squatrito, Chiara Luise, Nelofer Syed, Daniele Perna, Landon Wark, Francesca Martinato, Domenico Sardella, Alessandro Verrecchia, Samantha Bennett,…

  Source: Nature. 2007 Aug 30

  View Full Text

• DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization.

  Primary mouse embryonic fibroblasts (MEFs) are a popular tool for molecular and cell biology studies. However, when MEFs are grown in vitro under stan…

  Authors: Raffaella Di Micco, Angelo Cicalese, Marzia Fumagalli, Miryana Dobreva, Alessandro Verrecchia, Pier Giuseppe Pelicci, Fabrizio d'Adda di Fagagna

  Source: Cell cycle (Georgetown, Tex.). 2008 Nov 15

  View Full Text