1 to 10 of 27 literature results

• Identification of protein pheromones that promote aggressive behaviour.

  Mice use pheromones, compounds emitted and detected by members of the same species, as cues to regulate social behaviours such as pup suckling, aggres…

  Authors: Pablo Chamero, Tobias F Marton, Darren W Logan, Kelly Flanagan, Jason R Cruz, Alan Saghatelian, Benjamin F Cravatt, Lisa Stowers

  Source: Nature. 2007 Dec 6

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• Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk.

  Lactation is a highly demanding lipid synthesis and transport process that is crucial for the development of newborn mammals. While PPAR gamma is know…

  Authors: Yihong Wan, Alan Saghatelian, Ling-Wa Chong, Chun-Li Zhang, Benjamin F Cravatt, Ronald M Evans

  Source: Genes & development. 2007 Aug 1

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• Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.

  Chemical genomics aims to discover small molecules that affect biological processes through the perturbation of protein function. However, determining…

  Authors: Michael J Evans, Alan Saghatelian, Erik J Sorensen, Benjamin F Cravatt

  Source: Nature biotechnology. 2005 Oct

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• Expanding the Dipeptidyl Peptidase 4-Regulated Peptidome via an Optimized Peptidomics Platform.

  In recent years, the biological sciences have seen a surge in the development of methods, including high-throughput global methods, for the quantitati…

  Authors: Arthur D Tinoco, Debarati M Tagore, Alan Saghatelian

  Source: Journal of the American Chemical Society. 2010 Mar 24

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• Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling.

  Viruses rely upon host lipid metabolic pathways for successful replication, and there is increasing interest in these pathways as novel therapeutic ta…

  Authors: Mary A Rodgers, Alan Saghatelian, Priscilla L Yang

  Source: Journal of the American Chemical Society. 2009 Apr 15

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• A global metabolite profiling approach to identify protein-metabolite interactions.

  Understanding the biochemical functions of proteins is an important factor in elucidating their cellular and physiological functions. Due to the predo…

  Authors: Ranitendranath Tagore, Horatio R Thomas, Edwin A Homan, Ali Munawar, Alan Saghatelian

  Source: Journal of the American Chemical Society. 2008 Oct 29

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• A streamlined metabolic pathway for the biosynthesis of moenomycin A.

  Moenomycin A (MmA) is a member of the phosphoglycolipid family of antibiotics, which are the only natural products known to directly target the extrac…

  Authors: Bohdan Ostash, Alan Saghatelian, Suzanne Walker

  Source: Chemistry & biology. 2007 Mar

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• Global strategies to integrate the proteome and metabolome.

  A fundamental goal of proteomics is to assign physiological functions to all proteins encoded by eukaryotic and prokaryotic genomes. Of the many activ…

  Authors: Alan Saghatelian, Benjamin F Cravatt

  Source: Current opinion in chemical biology. 2005 Feb

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• An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.

  Hundreds, if not thousands, of uncharacterized enzymes currently populate the human proteome. Assembly of these proteins into the metabolic and signal…

  Authors: Kyle P Chiang, Sherry Niessen, Alan Saghatelian, Benjamin F Cravatt

  Source: Chemistry & biology. 2006 Oct

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• Peptidomics of prolyl endopeptidase in the central nervous system.

  Prolyl endopeptidase (Prep) is a member of the prolyl peptidase family and is of interest because of its unique biochemistry and connections to cognit…

  Authors: Whitney M Nolte, Debarati M Tagore, William S Lane, Alan Saghatelian

  Source: Biochemistry. 2009 Dec 22

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