1 to 10 of 18 literature results

• Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

  Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated l…

  Authors: Steven A McCarroll, Alan Huett, Petric Kuballa, Shannon D Chilewski, Aimee Landry, Philippe Goyette, Michael C Zody, Jennifer L Hall, Steven R Brant, Judy H Cho,…

  Source: Nature genetics. 2008 Sep

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• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

  We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of associa…

  Authors: John D Rioux, Ramnik J Xavier, Kent D Taylor, Mark S Silverberg, Philippe Goyette, Alan Huett, Todd Green, Petric Kuballa, M Michael Barmada, Lisa Wu Datta,…

  Source: Nature genetics. 2007 May

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• Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly.

  Ileal lesions in Crohn's disease (CD) patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) able to invade and to replicate w…

  Authors: Pierre Lapaquette, Anne-Lise Glasser, Alan Huett, Ramnik J Xavier, Arlette Darfeuille-Michaud

  Source: Cellular microbiology. 2010 Jan

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• Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases.

  Autophagy is a conserved homeostatic process by which cells degrade and recycle cytoplasmic contents and organelles. Recently, autophagy has come to p…

  Authors: Alan Huett, Ramnik J Xavier

  Source: Inflammatory bowel diseases. 2010 Jan

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• DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

  PDZ domain containing molecular scaffolds plays a central role in organizing synaptic junctions. Observations in Drosophila and mammalian cells have i…

  Authors: Zhifang Cao, Alan Huett, Petric Kuballa, Cosmas Giallourakis, Ramnik J Xavier

  Source: Cellular signalling. 2008 Jan

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• The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.

  The common gastrointestinal pathogens enteropathogenic Escherichia coli (EPEC) and Salmonella typhimurium both reorganize the gut epithelial cell acti…

  Authors: Alan Huett, John M Leong, Daniel K Podolsky, Ramnik J Xavier

  Source: Experimental cell research. 2009 Jul 15

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• Neither hide nor hair: the difficulty of identifying useful disease biomarkers.

  Authors: Alan Huett, Ramnik J Xavier

  Source: Gastroenterology. 2008 Jun

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• Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium.

  Citrobacter rodentium belongs to a family of human and animal enteric pathogens that includes the clinically significant enterohaemorrhagic Escherichi…

  Authors: Siouxsie Wiles, Simon Clare, James Harker, Alan Huett, Douglas Young, Gordon Dougan, Gad Frankel

  Source: Cellular microbiology. 2004 Oct

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• Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

  Authors: Ramnik J Xavier, Alan Huett, John D Rioux

  Source: Gut. 2008 Jun

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• SNPping away at the pathogenesis of Crohn's disease.

  Authors: Alan Huett, Ramnik Xavier

  Source: Inflammatory bowel diseases. 2008 Jan

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