1 to 10 of 60 literature results

• Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling.

  BACKGROUND & AIMS: Because of the lack of animal models developing spontaneous autoimmune hepatitis (AIH), the molecular mechanisms involved in the de…

  Authors: Masahiro Kido, Norihiko Watanabe, Taku Okazaki, Takuji Akamatsu, Junya Tanaka, Kazuyuki Saga, Akiyoshi Nishio, Tasuku Honjo, Tsutomu Chiba

  Source: Gastroenterology. 2008 Oct

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• Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production.

  BACKGROUND & AIMS: Thioredoxin-1 (TRX) is a small multifunctional protein with antioxidative and redox-regulating functions. In this study, we investi…

  Authors: Hiroyuki Tamaki, Hajime Nakamura, Akiyoshi Nishio, Hiroshi Nakase, Satoru Ueno, Norimitsu Uza, Masahiro Kido, Satoko Inoue, Sakae Mikami, Masanori Asada,…

  Source: Gastroenterology. 2006 Oct

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• Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis.

  BACKGROUND & AIMS: Basic fibroblast growth factor (bFGF) is a promising therapeutic agent for various diseases. It remains unclear, however, whether b…

  Authors: Minoru Matsuura, Kazuichi Okazaki, Akiyoshi Nishio, Hiroshi Nakase, Hiroyuki Tamaki, Kazushige Uchida, Toshiki Nishi, Masanori Asada, Kimio Kawasaki, Toshiro Fukui,…

  Source: Gastroenterology. 2005 Apr

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• Analysis of humoral immune response in experimental autoimmune pancreatitis in mice.

  OBJECTIVES: To study the autoimmune response in MRL/Mp mice, which spontaneously develop pancreatitis in the exocrine pancreatic tissue. METHODS: Six-…

  Authors: Masanori Asada, Akiyoshi Nishio, Takuji Akamatsu, Junya Tanaka, Kazuyuki Saga, Masahiro Kido, Norihiko Watanabe, Kazushige Uchida, Toshiro Fukui, Kazuichi Okazaki,…

  Source: Pancreas. 2010 Mar

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• Immunopathogenesis of primary biliary cirrhosis.

  Although the autoantigens of antimitochondrial antibodies (AMA) have been defined and epitope mapped for both autoreactive B and T cells, the pathogen…

  Authors: Akiyoshi Nishio, Emmet B Keeffe, M Eric Gershwin

  Source: Seminars in liver disease. 2002 Aug

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• Essential role of Peyer's patches in the development of Helicobacter-induced gastritis.

  Helicobacter bacteria colonize in the stomach and induce strong, specific local and systemic humoral and cell-mediated immunity. Helicobacter binds to…

  Authors: Keiichi Kiriya, Norihiko Watanabe, Akiyoshi Nishio, Kazuichi Okazaki, Masahiro Kido, Kazuyuki Saga, Junya Tanaka, Takuji Akamatsu, Shinya Ohashi, Masanori Asada,…

  Source: International immunology. 2007 Apr

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• Endocrine disruptors that deplete glutathione levels in APC promote Th2 polarization in mice leading to the exacerbation of airway inflammation.

  Endocrine-disrupting chemicals (EDC) are ubiquitous in environment and may have various undesirable effects on human health. In the present study, we …

  Authors: Takuma Kato, Saeko Tada-Oikawa, Kazuo Takahashi, Kanako Saito, Linan Wang, Akiyoshi Nishio, Rie Hakamada-Taguchi, Shosuke Kawanishi, Kagemasa Kuribayashi

  Source: European journal of immunology. 2006 May

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• Involvement of Smad3 phosphoisoform-mediated signaling in the development of colonic cancer in IL-10-deficient mice.

  Chronic inflammation predisposes to cancer. Transforming growth factor (TGF)-beta, a multifunctional protein, suppresses the growth of normal colonic …

  Authors: Daisaku Hachimine, Kazushige Uchida, Masanori Asada, Akiyoshi Nishio, Seiji Kawamata, Go Sekimoto, Miki Murata, Hideo Yamagata, Katsunori Yoshida, Shigeo Mori,…

  Source: International journal of oncology. 2008 Jun

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• Specific antibodies against recombinant protein of insertion element 900 of Mycobacterium avium subspecies paratuberculosis in Japanese patients with Crohn's disease.

  BACKGROUND: Mycobacterial avium subspecies paratuberculosis (MAP) infection has been hypothesized as an etiological factor of Crohn's disease (CD). Ho…

  Authors: Hiroshi Nakase, Akiyoshi Nishio, Hiroyuki Tamaki, Minoru Matsuura, Masanori Asada, Tsutomu Chiba, Kazuichi Okazaki

  Source: Inflammatory bowel diseases. 2006 Jan

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• Differential diagnosis of intraduodenal cystic lesions: choledochocele, duodenal duplication cyst, or intraluminal duodenal diverticulum?

  Authors: Mitsunobu Matsushita, Kazushige Uchida, Akiyoshi Nishio, Kazuichi Okazaki

  Source: Gastrointestinal endoscopy. 2010 Jan

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