1 to 8 of 8 literature results

• Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.

  Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. These findings rai…

  Authors: Markus Feuerer, Laura Herrero, Daniela Cipolletta, Afia Naaz, Jamie Wong, Ali Nayer, Jongsoon Lee, Allison B Goldfine, Christophe Benoist, Steven Shoelson,…

  Source: Nature medicine. 2009 Aug

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• Obesity, inflammation, and insulin resistance.

  Weight gain and obesity are major risk factors for conditions and diseases ranging from insulin resistance and type 2 diabetes mellitus to atheroscler…

  Authors: Steven E Shoelson, Laura Herrero, Afia Naaz

  Source: Gastroenterology. 2007 May

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• Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice.

  Equol, a metabolite of the phytoestrogen daidzein, is present at significant levels in some humans who consume soy and in rodents fed soy-based diets.…

  Authors: Vimal Selvaraj, Melissa A Zakroczymski, Afia Naaz, Motoko Mukai, Young H Ju, Daniel R Doerge, John A Katzenellenbogen, William G Helferich, Paul S Cooke

  Source: Biology of reproduction. 2004 Sep

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• The soy isoflavone genistein decreases adipose deposition in mice.

  Adipose tissue is responsive to estrogen and expresses both estrogen receptor alpha and beta. To test the hypothesis that the estrogenic soy isoflavon…

  Authors: Afia Naaz, Srikanth Yellayi, Melissa A Zakroczymski, David Bunick, Daniel R Doerge, Dennis B Lubahn, William G Helferich, Paul S Cooke

  Source: Endocrinology. 2003 Aug

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• Role of estrogens in adipocyte development and function.

  Estrogen has historically been viewed as a major regulator of adipose tissue in adult females, but recent work has indicated that estrogen's role in a…

  Authors: Paul S Cooke, Afia Naaz

  Source: Experimental biology and medicine (Maywood, N.J.). 2004 Dec

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• Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity.

  Adipocyte hyperplasia is characteristic of some forms of human obesity, but the role of adipocyte number in obesity and how normal adipocyte number is…

  Authors: Afia Naaz, Denise R Holsberger, Gary A Iwamoto, Amanda Nelson, Hiroaki Kiyokawa, Paul S Cooke

  Source: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 Dec

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• Effects of estrogens and the phytoestrogen genistein on adipogenesis and lipogenesis in males and females.

  Authors: Paul S Cooke, Afia Naaz

  Source: Birth defects research. Part A, Clinical and molecular teratology. 2005 Jul

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• The phytoestrogen genistein induces thymic and immune changes: a human health concern?

  Use of soy-based infant formulas and soy/isoflavone supplements has aroused concern because of potential estrogenic effects of the soy isoflavones gen…

  Authors: Srikanth Yellayi, Afia Naaz, Melissa A Szewczykowski, Tomomi Sato, Jeffrey A Woods, Jongsoo Chang, Mariangela Segre, Clint D Allred, William G Helferich, Paul S Cooke

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2002 May 28

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