1 to 7 of 7 literature results

• Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.

  Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop f…

  Authors: Elgene Lim, François Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen,…

  Source: Nature medicine. 2009 Aug

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• Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1.

  Mixl1 is a paired-type homeodomain protein that plays a crucial role in morphogenesis and endoderm differentiation in the murine embryo. To understand…

  Authors: Adam H Hart, Tracy A Willson, Michael Wong, Karen Parker, Lorraine Robb

  Source: Biochemical and biophysical research communications. 2005 Aug 12

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• The pluripotency homeobox gene NANOG is expressed in human germ cell tumors.

  BACKGROUND: The NANOG gene, a member of the homeobox family of DNA binding transcription factors, was recently identified in a screen for pluripotency…

  Authors: Adam H Hart, Lynne Hartley, Karen Parker, Marilyn Ibrahim, Leendert H J Looijenga, Marija Pauchnik, Chung Wo Chow, Lorraine Robb

  Source: Cancer. 2005 Nov 15

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• Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells.

  Leukemia inhibitory factor (LIF) is required to maintain pluripotency and permit self-renewal of murine embryonic stem (ES) cells. LIF binds to a rece…

  Authors: Ariel Forrai, Kristy Boyle, Adam H Hart, Lynne Hartley, Steven Rakar, Tracy A Willson, Ken M Simpson, Andrew W Roberts, Warren S Alexander, Anne K Voss,…

  Source: Stem cells (Dayton, Ohio). 2006 Mar

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• Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human.

  The murine Nanog gene, a member of the homeobox family of DNA binding transcription factors, has been shown recently to maintain pluripotency of embry…

  Authors: Adam H Hart, Lynne Hartley, Marilyn Ibrahim, Lorraine Robb

  Source: Developmental dynamics : an official publication of the American Association of Anatomists. 2004 May

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• Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.

  Mixl1, the sole murine homologue of the Xenopus Mix/Bix family of homeobox transcription factors, is essential for the patterning of axial mesendoderm…

  Authors: Stefan Glaser, Donald Metcalf, Li Wu, Adam H Hart, Ladina DiRago, Sandra Mifsud, Angela D'Amico, Samantha Dagger, Chiara Campo, Angela C Chan,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Oct 31

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• Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo.

  In Xenopus, the Mix/Bix family of homeobox genes has been implicated in mesendoderm development. Mixl1 is the only known murine member of this family.…

  Authors: Adam H Hart, Lynne Hartley, Koula Sourris, Elizabeth S Stadler, Ruili Li, Edouard G Stanley, Patrick P L Tam, Andrew G Elefanty, Lorraine Robb

  Source: Development (Cambridge, England). 2002 Aug

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