1 to 10 of 115 literature results

• Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation.

  Antibiotics target ribosomes at distinct locations within functionally relevant sites. They exert their inhibitory action by diverse modes, including …

  Authors: Ada Yonath

  Source: Annual review of biochemistry. 2005

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• Molecular biology: triggering positive competition.

  Authors: Ada Yonath

  Source: Nature. 2006 Nov 23

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• Correlating ribosome function with high-resolution structures.

  Ribosome research has undergone astonishing progress in recent years. Crystal structures have shed light on the functional properties of the translati…

  Authors: Anat Bashan, Ada Yonath

  Source: Trends in microbiology. 2008 Jul

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• The search and its outcome: high-resolution structures of ribosomal particles from mesophilic, thermophilic, and halophilic bacteria at various functional states.

  We determined the high-resolution structures of large and small ribosomal subunits from mesophilic and thermophilic bacteria and compared them with th…

  Authors: Ada Yonath

  Source: Annual review of biophysics and biomolecular structure. 2002

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• Ribosomal crystallography: initiation, peptide bond formation, and amino acid polymerization are hampered by antibiotics.

  High-resolution structures of ribosomal complexes revealed that minute amounts of clinically relevant antibiotics hamper protein biosynthesis by limit…

  Authors: Ada Yonath, Anat Bashan

  Source: Annual review of microbiology. 2004

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• Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria.

  Ribosomes, the site of protein synthesis, are a major target for natural and synthetic antibiotics. Detailed knowledge of antibiotic binding sites is …

  Authors: F Schlünzen, R Zarivach, J Harms, A Bashan, A Tocilj, R Albrecht, A Yonath, F Franceschi

  Source: Nature. 2001 Oct 25

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• Ribosomal antibiotics: structural basis for resistance, synergism and selectivity.

  Various antibiotics bind to ribosomes at functionally relevant locations such as the peptidyl-transferase center (PTC) and the exit tunnel for nascent…

  Authors: Tamar Auerbach, Anat Bashan, Ada Yonath

  Source: Trends in biotechnology. 2004 Nov

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• High resolution structure of the large ribosomal subunit from a mesophilic eubacterium.

  We describe the high resolution structure of the large ribosomal subunit from Deinococcus radiodurans (D50S), a gram-positive mesophile suitable for b…

  Authors: J Harms, F Schluenzen, R Zarivach, A Bashan, S Gat, I Agmon, H Bartels, F Franceschi, A Yonath

  Source: Cell. 2001 Nov 30

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• The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery.

  Structural analysis supported by biochemical, mutagenesis and computational evidence, revealed that the contemporary ribosome's active site is a unive…

  Authors: Chen Davidovich, Matthew Belousoff, Anat Bashan, Ada Yonath

  Source: Research in microbiology. 2009 Sep

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• Structural insight into the role of the ribosomal tunnel in cellular regulation.

  Nascent proteins emerge out of ribosomes through an exit tunnel, which was assumed to be a firmly built passive path. Recent biochemical results, howe…

  Authors: Rita Berisio, Frank Schluenzen, Joerg Harms, Anat Bashan, Tamar Auerbach, David Baram, Ada Yonath

  Source: Nature structural biology. 2003 May

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