1 to 10 of 113 literature results

• Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation.

  Antibiotics target ribosomes at distinct locations within functionally relevant sites. They exert their inhibitory action by diverse modes, including …

  Authors: Ada Yonath

  Source: Annual review of biochemistry. 2005

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• Molecular biology: triggering positive competition.

  Authors: Ada Yonath

  Source: Nature. 2006 Nov 23

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• Correlating ribosome function with high-resolution structures.

  Ribosome research has undergone astonishing progress in recent years. Crystal structures have shed light on the functional properties of the translati…

  Authors: Anat Bashan, Ada Yonath

  Source: Trends in microbiology. 2008 Jul

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• The search and its outcome: high-resolution structures of ribosomal particles from mesophilic, thermophilic, and halophilic bacteria at various functional states.

  We determined the high-resolution structures of large and small ribosomal subunits from mesophilic and thermophilic bacteria and compared them with th…

  Authors: Ada Yonath

  Source: Annual review of biophysics and biomolecular structure. 2002

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• Ribosomal crystallography: initiation, peptide bond formation, and amino acid polymerization are hampered by antibiotics.

  High-resolution structures of ribosomal complexes revealed that minute amounts of clinically relevant antibiotics hamper protein biosynthesis by limit…

  Authors: Ada Yonath, Anat Bashan

  Source: Annual review of microbiology. 2004

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• Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria.

  Ribosomes, the site of protein synthesis, are a major target for natural and synthetic antibiotics. Detailed knowledge of antibiotic binding sites is …

  Authors: F Schlünzen, R Zarivach, J Harms, A Bashan, A Tocilj, R Albrecht, A Yonath, F Franceschi

  Source: Nature. 2001 Oct 25

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• High resolution structure of the large ribosomal subunit from a mesophilic eubacterium.

  We describe the high resolution structure of the large ribosomal subunit from Deinococcus radiodurans (D50S), a gram-positive mesophile suitable for b…

  Authors: J Harms, F Schluenzen, R Zarivach, A Bashan, S Gat, I Agmon, H Bartels, F Franceschi, A Yonath

  Source: Cell. 2001 Nov 30

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• Ribosomal antibiotics: structural basis for resistance, synergism and selectivity.

  Various antibiotics bind to ribosomes at functionally relevant locations such as the peptidyl-transferase center (PTC) and the exit tunnel for nascent…

  Authors: Tamar Auerbach, Anat Bashan, Ada Yonath

  Source: Trends in biotechnology. 2004 Nov

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• Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression.

  Crystal structures of tRNA mimics complexed with the large ribosomal subunit of Deinococcus radiodurans indicate that remote interactions determine th…

  Authors: Anat Bashan, Ilana Agmon, Raz Zarivach, Frank Schluenzen, Joerg Harms, Rita Berisio, Heike Bartels, Francois Franceschi, Tamar Auerbach, Harly A S Hansen,…

  Source: Molecular cell. 2003 Jan

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• Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution.

  The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows tha…

  Authors: F Schluenzen, A Tocilj, R Zarivach, J Harms, M Gluehmann, D Janell, A Bashan, H Bartels, I Agmon, F Franceschi,…

  Source: Cell. 2000 Sep 1

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