1 to 10 of 2,550 literature results

• Endocannabinoid-mediated synaptic plasticity in the CNS.

  Changes in synaptic efficacy are thought to be crucial to experience-dependent modifications of neural function. The diversity of mechanisms underlyin…

  Authors: Vivien Chevaleyre, Kanji A Takahashi, Pablo E Castillo

  Source: Annual review of neuroscience. 2006

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• A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.

  Chronic hepatitis B is a serious infectious liver disease that often progresses to liver cirrhosis and hepatocellular carcinoma; however, clinical out…

  Authors: Yoichiro Kamatani, Sukanya Wattanapokayakit, Hidenori Ochi, Takahisa Kawaguchi, Atsushi Takahashi, Naoya Hosono, Michiaki Kubo, Tatsuhiko Tsunoda, Naoyuki Kamatani, Hiromitsu Kumada,…

  Source: Nature genetics. 2009 May

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• Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population.

  Rheumatoid arthritis is a chronic autoimmune inflammatory disease with a complex genetic etiology. Members of the signaling lymphocyte activation mole…

  Authors: Akari Suzuki, Ryo Yamada, Yuta Kochi, Tetsuji Sawada, Yukinori Okada, Koichi Matsuda, Yoichiro Kamatani, Mikako Mori, Kenichi Shimane, Yasuhiko Hirabayashi,…

  Source: Nature genetics. 2008 Oct

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• Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis.

  Susceptibility to osteoarthritis, the most common human arthritis, is known to be influenced by genetic factors. Through a genome-wide association stu…

  Authors: Yoshinari Miyamoto, Dongquan Shi, Masahiro Nakajima, Kouichi Ozaki, Akihiro Sudo, Akihiro Kotani, Atsumasa Uchida, Toshihiro Tanaka, Naoshi Fukui, Tatsuhiko Tsunoda,…

  Source: Nature genetics. 2008 Aug

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• A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.

  Ulcerative colitis is one of the principal forms of inflammatory bowel disease with complex manifestations. Although previous studies have indicated t…

  Authors: Kouichi Asano, Tomonaga Matsushita, Junji Umeno, Naoya Hosono, Atsushi Takahashi, Takahisa Kawaguchi, Takayuki Matsumoto, Toshiyuki Matsui, Yoichi Kakuta, Yoshitaka Kinouchi,…

  Source: Nature genetics. 2009 Dec

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• A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population.

  Inflammation is now considered critical in the pathogenesis of myocardial infarction. One of the mechanisms regulating the inflammatory process is the…

  Authors: Kouichi Ozaki, Hiroshi Sato, Aritoshi Iida, Hiroya Mizuno, Takahiro Nakamura, Yoshinari Miyamoto, Atsushi Takahashi, Tatsuhiko Tsunoda, Shiro Ikegawa, Naoyuki Kamatani,…

  Source: Nature genetics. 2006 Aug

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• Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

  Insulin resistance is often associated with obesity and can precipitate type 2 diabetes. To date, most known approaches that improve insulin resistanc…

  Authors: Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, Toyonori Kato, Ayaka Atsumi, Takashi Yamamoto, Noriyuki Inoue, Mayumi Ishikawa, Sumiyo Okada, Naomi Ishigaki,…

  Source: Nature medicine. 2007 Oct

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• TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.

  Using an expression cloning strategy, we have identified TFE3, a basic helix-loop-helix protein, as a transactivator of metabolic genes that are regul…

  Authors: Yoshimi Nakagawa, Hitoshi Shimano, Tomohiro Yoshikawa, Tomohiro Ide, Mariko Tamura, Mika Furusawa, Takashi Yamamoto, Noriyuki Inoue, Takashi Matsuzaka, Akimitsu Takahashi,…

  Source: Nature medicine. 2006 Jan

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• Mechanically driven ATP synthesis by F1-ATPase.

  ATP, the main biological energy currency, is synthesized from ADP and inorganic phosphate by ATP synthase in an energy-requiring reaction. The F1 port…

  Authors: Hiroyasu Itoh, Akira Takahashi, Kengo Adachi, Hiroyuki Noji, Ryohei Yasuda, Masasuke Yoshida, Kazuhiko Kinosita

  Source: Nature. 2004 Jan 29

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• Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.

  BACKGROUND & AIMS: Esophageal squamous cell carcinoma (ESCC) is prevalent among Asian populations, with marked regional variations in incidence and mo…

  Authors: Ri Cui, Yoichiro Kamatani, Atsushi Takahashi, Masayuki Usami, Naoya Hosono, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Naoyuki Kamatani, Michiaki Kubo, Yusuke Nakamura,…

  Source: Gastroenterology. 2009 Nov

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