1 to 10 of 59 literature results

• Diabetic pregnancies: the challenge of developing in a pro-inflammatory environment.

  The maternal diabetic environment alters the embryo and the feto-placental development. The results of these alterations are: increased embryo resorpt…

  Authors: A Jawerbaum, E González

  Source: Current medicinal chemistry. 2006

  View Full Text

• The role of alterations in arachidonic acid metabolism and nitric oxide homeostasis in rat models of diabetes during early pregnancy.

  The diabetic pathology induces reproductive abnormalities that enhance spontaneous abortion, congenital anomalies and neonatal morbidity/mortality rat…

  Authors: A Jawerbaum, E Gonzalez

  Source: Current pharmaceutical design. 2005

  View Full Text

• Safflower and olive oil dietary treatments rescue aberrant embryonic arachidonic acid and nitric oxide metabolism and prevent diabetic embryopathy in rats.

  Aberrant arachidonic acid and nitric oxide (NO) metabolic pathways are involved in diabetic embryopathy. Previous works have found diminished concentr…

  Authors: R Higa, V White, N Martínez, M Kurtz, E Capobianco, A Jawerbaum

  Source: Molecular human reproduction. 2010 Apr

  View Full Text

• Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats.

  Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-dependent nuclear receptor that plays an important role in placental developm…

  Authors: Evangelina Capobianco, Verónica White, Romina Higa, Nora Martínez, Alicia Jawerbaum

  Source: Molecular human reproduction. 2008 Aug

  View Full Text

• MMP/ TIMP balance is modulated in vitro by 15dPGJ(2) in fetuses and placentas from diabetic rats.

  BACKGROUND: Maternal diabetes is associated with morphological placental abnormalities and foeto-placental impairments. These alterations are linked w…

  Authors: M C Pustovrh, E Capobianco, N Martínez, R Higa, V White, A Jawerbaum

  Source: European journal of clinical investigation. 2009 Dec

  View Full Text

• PPARdelta and its activator PGI2 are reduced in diabetic embryopathy: involvement of PPARdelta activation in lipid metabolic and signalling pathways in rat embryo early organogenesis.

  Maternal diabetes significantly increases the risk of congenital malformations, and the mechanisms involved are not yet clarified. This study was desi…

  Authors: R Higa, E González, M C Pustovrh, V White, E Capobianco, N Martínez, A Jawerbaum

  Source: Molecular human reproduction. 2007 Feb

  View Full Text

• Increased matrix metalloproteinases 2 and 9 in placenta of diabetic rats at midgestation.

  Matrix metalloproteinases (MMPs) are involved in placental remodelling throughout pregnancy. Diabetes mellitus induces alterations in tissue productio…

  Authors: M C Pustovrh, A Jawerbaum, E Capobianco, V White, J J López-Costa, E González

  Source: Placenta. 2005 Apr

  View Full Text

• Influence of peroxisome proliferator-activated receptor gamma activation by its endogenous ligand 15-deoxy Delta12,14 prostaglandin J2 on nitric oxide production in term placental tissues from diabetic women.

  Diabetes induces alterations which condition placental remodelling. The levels of nitric oxide (NO) (a modulator of placental invasiveness, differenti…

  Authors: A Jawerbaum, E Capobianco, C Pustovrh, V White, M Baier, S Salzberg, M Pesaresi, E Gonzalez

  Source: Molecular human reproduction. 2004 Sep

  View Full Text

• Oxidative stress promotes the increase of matrix metalloproteinases-2 and -9 activities in the feto-placental unit of diabetic rats.

  Maternal diabetes increases the risk of congenital malformations, placental dysfunction and diseases in both the neonate and the offspring's later lif…

  Authors: María Carolina Pustovrh, Alicia Jawerbaum, Evangelina Capobianco, Verónica White, Nora Martínez, Juan José López-Costa, Elida González

  Source: Free radical research. 2005 Dec

  View Full Text

• The effects of maternal dietary treatments with natural PPAR ligands on lipid metabolism in fetuses from control and diabetic rats.

  Maternal diabetes impairs fetal development and growth. We studied the effects of maternal diets enriched in unsaturated fatty acids capable of activa…

  Authors: E Capobianco, N Martínez, R Higa, V White, A Jawerbaum

  Source: Prostaglandins, leukotrienes, and essential fatty acids. 2008 Dec

  View Full Text