1 to 10 of 60 literature results

• Predicting the time of conversion to MCI in the elderly: role of verbal expression and learning.

  BACKGROUND: Increasing awareness that minimal or mild cognitive impairment (MCI) in the elderly may be a precursor of dementia has led to an increase …

  Authors: Abderrahim Oulhaj, Gordon K Wilcock, A David Smith, Celeste A de Jager

  Source: Neurology. 2009 Nov 3

  View Full Text

• Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

  We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS…

  Authors: Denise Harold, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Marian L Hamshere, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Amy Williams,…

  Source: Nature genetics. 2009 Oct

  View Full Text

• Epistasis in sporadic Alzheimer's disease.

  The traditional approach in case-control association studies, to evaluate candidate genes individually, either single markers or haplotypes, has had l…

  Authors: Onofre Combarros, Mario Cortina-Borja, A David Smith, Donald J Lehmann

  Source: Neurobiology of aging. 2009 Sep

  View Full Text

• PSEN1 polymorphisms alter the rate of cognitive decline in sporadic Alzheimer's disease patients.

  Mutations in amyloid precursor protein (APP) and presenilin (PSEN) genes are known to cause familial early-onset Alzheimer's disease (AD), which accou…

  Authors: Olivia Belbin, Helen Beaumont, Donald Warden, A David Smith, Noor Kalsheker, Kevin Morgan

  Source: Neurobiology of aging. 2009 Dec

  View Full Text

• Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease.

  Alzheimer's disease (AD) is characterized by a complex neurodegenerative process affecting multiple genes and proteins in the neocortex, many of which…

  Authors: Michelle G Tan, Wei-Ting Chua, Margaret M Esiri, A David Smith, Harry V Vinters, Mitchell K Lai

  Source: Journal of neuroscience research. 2010 May 1

  View Full Text

• Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status.

  BACKGROUND: Methylmalonic acid (MMA) in plasma or serum is widely used for assessment of vitamin B(12) status. However, data are sparse regarding fact…

  Authors: Anna Vogiatzoglou, Abderrahim Oulhaj, A David Smith, Eha Nurk, Christian A Drevon, Per M Ueland, Stein E Vollset, Grethe S Tell, Helga Refsum

  Source: Clinical chemistry. 2009 Dec

  View Full Text

• Numerical simulations of long-range plasmons.

  We present simulations of plasmonic transmission lines consisting of planar metal strips embedded in isotropic dielectric media, with a particular emp…

  Authors: Aloyse Degiron, David Smith

  Source: Optics express. 2006 Feb 20

  View Full Text

• Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal.

  BACKGROUND: There remains a lack of consensus regarding the optimal treatment for patients with curable adenocarcinoma of the anal canal (AAC). We sou…

  Authors: Nicole Kounalakis, Avo Artinyan, David Smith, Pablo Mojica-Manoso, Benjamin Paz, Lily L Lai

  Source: Annals of surgical oncology. 2009 May

  View Full Text

• Blood pressure, dementia and Alzheimer's disease: the OPTIMA longitudinal study.

  BACKGROUND/AIMS: Studies on the relation between blood pressure (BP), dementia and Alzheimer's disease (AD) have yielded inconsistent results, showing…

  Authors: George Razay, Jonathan Williams, Elizabeth King, A David Smith, Gordon Wilcock

  Source: Dementia and geriatric cognitive disorders. 2009

  View Full Text

• Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study.

  We examined the relation between plasma total homocysteine (tHcy), folate, vitamin B12, and episodic memory in elderly community-dwelling subjects. A …

  Authors: Eha Nurk, Helga Refsum, Grethe S Tell, Knut Engedal, Stein E Vollset, Per M Ueland, Harald A Nygaard, A David Smith

  Source: Annals of neurology. 2005 Dec

  View Full Text