1 to 10 of 617 literature results

• Glycolysis: a bioenergetic or a survival pathway?

  Following inhibition of mitochondrial respiration neurons die rapidly, whereas astrocytes utilize glycolytically-generated ATP to increase their mitoc…

  Authors: Juan P Bolaños, Angeles Almeida, Salvador Moncada

  Source: Trends in biochemical sciences. 2010 Mar

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• The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

  Neurons are known to have a lower glycolytic rate than astrocytes and when stressed they are unable to upregulate glycolysis because of low Pfkfb3 (6-…

  Authors: Angel Herrero-Mendez, Angeles Almeida, Emilio Fernández, Carolina Maestre, Salvador Moncada, Juan P Bolaños

  Source: Nature cell biology. 2009 Jun

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• Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.

  After inhibition of cytochrome c oxidase by nitric oxide, astrocytes maintain energy production by upregulating glycolysis--a response which does not …

  Authors: Angeles Almeida, Salvador Moncada, Juan P Bolaños

  Source: Nature cell biology. 2004 Jan

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• Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications.

  Mitochondria represent both the main source and target of reactive oxygen and nitrogen species (RONS). In view of the large energy expenditure made by…

  Authors: Juan P Bolaños, Maria A Moro, Ignacio Lizasoain, Angeles Almeida

  Source: Advanced drug delivery reviews. 2009 Nov 30

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• The impact of age on emotional and cognitive behaviours triggered by experimental neuropathy in rats.

  Chronic pain syndromes encompass several clinical entities that frequently affect the individuals' emotional and cognitive behaviours which, in turn, …

  Authors: Hugo Leite-Almeida, Luis Almeida-Torres, Ana Raquel Mesquita, Antti Pertovaara, Nuno Sousa, João José Cerqueira, Armando Almeida

  Source: Pain. 2009 Jul

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• Genotyping of Giardia duodenalis cysts by new real-time PCR assays for detection of mixed infections in human samples.

  Of the seven genetic groups, or assemblages, currently recognized in the Giardia duodenalis species complex, only assemblages A and B are associated w…

  Authors: Andre Almeida, Edoardo Pozio, Simone M Cacciò

  Source: Applied and environmental microbiology. 2010 Mar

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• Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation.

  In neuroblastoma cells, retinoic acid induces cell cycle arrest and differentiation through degradation of the F-box protein, Skp2, and stabilization …

  Authors: J Cuende, S Moreno, J P Bolaños, A Almeida

  Source: Oncogene. 2008 May 22

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• Enhanced pronociception by amygdaloid group I metabotropic glutamate receptors in nerve-injured animals.

  Peripheral neuropathy has been associated with structural and functional changes of the amygdala, a key player in emotions. Here we study whether peri…

  Authors: Osei B Ansah, Leonor Gonçalves, Armando Almeida, Antti Pertovaara

  Source: Experimental neurology. 2009 Mar

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• The medullary dorsal reticular nucleus as a pronociceptive centre of the pain control system.

  The endogenous pain control system has long been considered as engaged in pain depression through the commitment of multiple descending actions that r…

  Authors: Deolinda Lima, Armando Almeida

  Source: Progress in neurobiology. 2002 Feb

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• Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.

  High levels of unconjugated bilirubin (UCB) may initiate encephalopathy in neonatal life, mainly in pre-mature infants. The molecular mechanisms of th…

  Authors: Ana Rita Vaz, Maria Delgado-Esteban, Maria Alexandra Brito, Juan P Bolaños, Dora Brites, Angeles Almeida

  Source: Journal of neurochemistry. 2010 Jan 1

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