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A bioactivity-guided fractionation of an extract of Terminalia bellerica fruit rind led to the isolation of two new lignans named termilignan (1) and thannilignan (2), together with 7-hydroxy-3',4'-(methylenedioxy)flavan (3) and anolignan B (4). All four compounds possessed demonstrable anti-HIV-1, antimalarial, and antifungal activity in vitro.


R Valsaraj, P Pushpangadan, U W Smitt, A Adsersen, S B Christensen, A Sittie, U Nyman, C Nielsen, C E Olsen. New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica. Journal of natural products. 1997 Jul;60(7):739-42

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PMID: 9249982

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