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The structures of antiviral antibiotics kistamicins A and B have been determined by a combination of chemical degradation and spectral analysis. They are commonly composed of D-tyrosine, 3,5-dihydrophenylglycine, a biphenyl ether bis-amino acid, and a diphenyl substituted indole tris-amino acid, forming a tricyclic ring structure. Kistamicin B possessed a phenethylamide at the amino terminal of kistamicin A. They are structurally related to the nuclei of the vancomycin group antibiotics particularly to antibiotic complestatin.

Citation

N Naruse, M Oka, M Konishi, T Oki. New antiviral antibiotics, kistamicins A and B. II. Structure determination. The Journal of antibiotics. 1993 Dec;46(12):1812-8

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PMID: 8294238

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