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Ultrastructural examinations of renal glomeruli in a case of diffuse mesangial sclerosis revealed a hitherto unknown type of alteration of the basement membranes ("cloudy pattern") which suggests a disturbance of glomerular basement membrane development as the basic mechanism which leads to therapy resistent infantile nephrotic syndrome.


H J Rumpelt, H J Bachmann. Infantile nephrotic syndrome with diffuse mesangial sclerosis: a disturbance of glomerular basement membrane development? Clinical nephrology. 1980 Mar;13(3):146-50

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PMID: 7379364

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