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The coeliac active peptide B 3142, which has been isolated from a peptic-tryptic digest of gliadin and which consists of 53 amino-acid sequences, was partially hydrolyzed with alpha-chymotrypsin. The two fragment peptides CT-1 (positions 1-22 of B 3142) and CT-2 (positions 23-53) were separated by high-performance liquid chromatography on octadecyl silica gel and purified by gel filtration on Biogel P2. The examination in the organ-culture test including 18 coeliac patients on normal diet and 7 control persons have shown that the toxicity is preserved after the chymotryptic treatment and that the peptides B 3142, CT-1 and CT-2 do not significantly differ from one another according to their coeliac-specific effect.


H Wieser, H D Belitz, D Idar, A Ashkenazi. Coeliac activity of the gliadin peptides CT-1 and CT-2. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. 1986 Feb;182(2):115-7

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PMID: 3705771

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