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A robust, convergent, and efficient strategy was developed for the synthesis of the nonasaccharide cancer antigen KH-1. This strategy featured a one-pot block assembly of the linear hexasaccharide backbone using three disaccharides followed by grafting of three fucose residues onto the backbone in one step.


Qingjiang Li, Zhongwu Guo. Synthesis of the Cancer-Associated KH-1 Antigen by Block Assembly of Its Backbone Structure Followed by One-Step Grafting of Three Fucose Residues. Organic letters. 2017 Nov 29

PMID: 29185761

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