Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Legionella pneumophila (L. pneumophila) is an intracellular bacterium which can be survived in the human macrophages phagosomes. The infectious agent is cleared in some cases and survived in others. The main mechanisms responsible for survival of L. pneumophila are yet to be clarified. It has been reported that innate immunity plays key roles in limitation and also eradication of bacterial infections. Toll like receptor 2 (TLR2) is an important cell membrane receptor which recognizes a wide range of bacterial antigens entitled pathogen associated molecular patterns (PAMPs). The aim of the current review article is to present recent data regarding the roles of TLR2 in induction of immune responses and consequently eradication of L. pneumophila. Additionally, the main mechanisms used by L. pneumophila to overcome TLR2 dependent immune responses are discussed in this review article. Copyright © 2017 Elsevier Inc. All rights reserved.


Shiva Ahmadishoar, Ashraf Kariminik. Toll-like receptor 2 and its roles in immune responses against Legionella pneumophila. Life sciences. 2017 Nov 01;188:158-162

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 28887059

View Full Text