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The heart has a markedly limited capacity for regeneration. Reporting in Nature, Bassat et al. (2017) and Morikawa et al. (2017) have uncovered a new mechanism of Yap inhibition by the dystrophin glycoprotein complex (DGC) that is released by the extracellular matrix protein Agrin in order to promote cardiac regeneration. Copyright © 2017 Elsevier Inc. All rights reserved.


Elif Eroglu, Kenneth R Chien. Heart Regeneration 4.0: Matrix Medicine. Developmental cell. 2017 Jul 10;42(1):7-8

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PMID: 28697334

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