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Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane-cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. demonstrate that RAS association domain family 4 (RASSF4) positively influences PI(4,5)P2 synthesis through ARF6-dependent regulation of PIP5K. © 2017 Dickson.


Eamonn J Dickson. RASSF4: Regulator of plasma membrane PI(4,5)P2. The Journal of cell biology. 2017 Jul 03;216(7):1879-1881

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PMID: 28634262

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