Clear Search sequence regions

  • BCL2 (1)
  • cell (3)
  • cell movement (1)
  • CREB1 (1)
  • distant metastases (1)
  • gastric cancer (7)
  • gastric mucosa (1)
  • gene (2)
  • humans (2)
  • KIF26B (7)
  • lymph node (2)
  • male (1)
  • metastasis (6)
  • mice (1)
  • micrornas (3)
  • MIRN372 (1)
  • oncogenes (1)
  • patients (1)
  • PIK3CA (1)
  • poor prognosis (1)
  • prognosis (1)
  • signal (1)
  • stomach neoplasms (1)
  • tumor metastasis (1)
  • tumor size (1)
  • VEGF (5)
  • VEGFA (1)
  • vitro (1)
  • Sizes of these terms reflect their relevance to your search.

    Tumor metastasis is the main reason of cancer-related death for gastric cancer (GC) patients and gene expression microarray data indicate that kinesin family member 26B (KIF26B) is one of the most upregulated genes in metastatic GC samples. Specifically, KIF26B expression was upregulated in a stepwise manner from non-tumorous gastric mucosa, primary GC tissues without metastasis, via primary GC tissues with metastasis, to secondary lymph node metastatic (LNM) foci. Increased expression of KIF26B was correlated with tumor size, positive LNM or distant metastases and poor prognosis. KIF26B, negatively regulated by miR-372, promoted GC cell proliferation and metastasis in vitro and in vivo. Mechanistic investigations confirmed that the main target of KIF26B was the vascular endothelial growth factor (VEGF) signaling pathway, particularly by inhibition or overexpression of VEGFA, PXN, FAK, PIK3CA, BCL2 and CREB1. Thus, KIF26B, a novel oncogene regulated by miR-372, promotes proliferation and metastasis through the VEGF pathway in GC.


    H Zhang, R-R Ma, X-J Wang, Z-X Su, X Chen, D-B Shi, X-Y Guo, H-T Liu, P Gao. KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer. Oncogene. 2017 Oct 05;36(40):5609-5619

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 28581513

    View Full Text