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Autoimmune neutropenia (AIN) is a rare disorder that may cause life-threatening infections. In adults, most cases are secondary to other pathological conditions, and primary AIN is extremely rare. We herein report a case involving a 57-year-old woman diagnosed with AIN. A granulocyte immunofluorescence test detected autoantibodies against human neutrophil antigens in her serum, while various examinations revealed no other causes of neutropenia, suggesting her AIN was primary. She was refractory to granulocyte-colony-stimulating factor but responded to prednisolone. Her neutrophil count remained normal after gradual discontinuation of prednisolone. Diagnostic procedures and optimal treatments for this disorder need to be established.


Mari Fujita, Hiroshi Kawabata, Tomomi Oka, Masakatsu Hishizawa, Toshiyuki Kitano, Tadakazu Kondo, Kohei Yamashita, Kimiko Yurugi, Hideyo Hirai, Taira Maekawa, Akifumi Takaori-Kondo. A Rare Case of Adult Autoimmune Neutropenia Successfully Treated with Prednisolone. Internal medicine (Tokyo, Japan). 2017;56(11):1415-1419

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PMID: 28566608

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