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During development, renin cells are precursors for arteriolar smooth muscle, mesangial cells, and interstitial pericytes. Those seemingly differentiated descendants retain the memory to re-express renin when there is a threat to homeostasis. Understanding how such molecular memory is constructed and regulated would be crucial to comprehend cell identity which is, in turn, intimately linked to homeostasis.

Citation

R Ariel Gomez, Maria Luisa S Sequeira Lopez. Plasticity of Renin Cells in the Kidney Vasculature. Current hypertension reports. 2017 Feb;19(2):14

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PMID: 28233238

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