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Endotoxemia is a life-threatening situation that signifies a key challenge in the field of intensive care medicine. Proinflammatory mediators produced by macrophages play a key role in endotoxemia. Gelsolin (GSN) is involved in the process of inflammation. IL-6 and TNF-α in the supernatant were measured with an ELISA kit. NO production was assessed by measurement of nitrite concentration with the Griess assay. si-RNA directed against GSN (si-GSN) was transfected by Lipofectamine. LPS decreased the levels of GSN. Recombinant GSN inhibited the cytokines induced by LPS and rescued mice from LPS-induced death, and si-GSN increased death in the LPS-pretreated mice. GSN exhibited a protective role in endotoxemia. © 2017 The Author(s) Published by S. Karger AG, Basel.

Citation

Ying Cheng, Xuguang Hu, Cong Liu, Ming Chen, Jianing Wang, Mingyu Wang, Fu Gao, Jiaqi Han, Chaoxiong Zhang, Ding Sun, Rui Min. Gelsolin Inhibits the Inflammatory Process Induced by LPS. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017;41(1):205-212

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PMID: 28135711

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