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    The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

    Citation

    Shuzo Urata, Jacqueline Weyer, Nadia Storm, Yukiko Miyazaki, Petrus Jansen van Vuren, Janusz Tadeusz Paweska, Jiro Yasuda. Analysis of Assembly and Budding of Lujo Virus. Journal of virology. 2016 Mar;90(6):3257-61

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    PMID: 26719243

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