Clear Search sequence regions


  • antitumor (4)
  • apoptosis (5)
  • Bcl 2 (1)
  • cells (6)
  • DFF 45 (1)
  • dna (1)
  • fruit (1)
  • garcinia (2)
  • garcinol (9)
  • human cells (2)
  • humans (2)
  • male (1)
  • mice (2)
  • PARP (1)
  • prostate (2)
  • tumor size (1)
  • xenograft (3)
  • Sizes of these terms reflect their relevance to your search.

    Garcinol, which is isolated from fruit rinds of Garcinia indica, is a polyisoprenylated benzophenone. It has been studied for its antitumor activity by inducing apoptosis and inhibiting autophagy in human prostate cancer cells. The Bax/Bcl-2 ratio increased when garcinol was applied to PC-3 cells indicating a presence of apoptosis. Meanwhile, procaspases-9 and -3 were suppressed with attenuating PARP and DFF-45. Autophagy was inhibited through activating p-mTOR and p-PI3 Kinase/AKT by garcinol, which as a result induced the cells to apoptosis directly. In addition, the apoptosis effect of garcinol in a xenograft mouse model was also tested, suggesting a consistent result with PC-3 cell model. The tumor size was reduced more than 80 percent after the mouse accepted the garcinol treatment. Garcinol was demonstrated to have a strong antitumor activity through inhibiting autophagy and inducing apoptosis, which was discovered for the first time. Based on these findings, our data suggests that garcinol deserves further investigation as a potent chemopreventive agent.

    Citation

    Yu Wang, Mei-Ling Tsai, Li-Yu Chiou, Chi-Tang Ho, Min-Hsiung Pan. Antitumor Activity of Garcinol in Human Prostate Cancer Cells and Xenograft Mice. Journal of agricultural and food chemistry. 2015 Oct 21;63(41):9047-52

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 26442822

    View Full Text