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Hundreds of RNA-binding proteins are known, but the biological functions are known for only a few of them. They regulate various aspects of RNA processing or biogenesis such as splicing, polyadenylation, and translation. Here I describe a bioinformatics approach that we developed to identify potential new mRNA target(s) of the Drosophila master sex-switch protein Sex-lethal (SXL) by combining computational analysis with genetic and biochemical investigation. This approach could be used to identify new RNA-protein interactions during oogenesis in the female germline and should be applicable to numerous other posttranscriptional regulatory events.


Ravinder Singh. Bioinformatics Analysis to Identify RNA-Protein Interactions in Oogenesis. Methods in molecular biology (Clifton, N.J.). 2015;1328:231-41

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PMID: 26324442

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