Clear Search sequence regions


  • alpinetin (10)
  • alpinia (2)
  • blood urea nitrogen (1)
  • cytokines (1)
  • factor (2)
  • flavonoid (1)
  • gene (1)
  • Heme (2)
  • Hmox1 protein (1)
  • humans (1)
  • IL 1β (1)
  • il 6 (1)
  • interleukin 1beta (2)
  • male (1)
  • mice (3)
  • mice balb c (1)
  • NF E2 (2)
  • NF κB (3)
  • nfe2l2 protein (1)
  • Nrf2 (2)
  • oxygen (2)
  • plant (1)
  • ROS (1)
  • species (2)
  • TLR4 (2)
  • TNF α (1)
  • Tumor Necrosis Factor (2)
  • western blot (1)
  • Sizes of these terms reflect their relevance to your search.

    Alpinetin, a novel plant flavonoid isolated from Alpinia katsumadai Hayata, has been demonstrated to have anti-inflammatory and antioxidant effects. However, the effects of alpinetin on lipopolysaccharide (LPS)-induced acute kidney injury have not been reported. In the present study, we investigated the protective effects and the underlying mechanism of alpinetin against LPS-induced acute kidney injury in mice. The results showed that alpinetin inhibited LPS-induced kidney histopathologic changes, blood urea nitrogen (BUN) and creatinine levels. Alpinetin also inhibited LPS-induced ROS, MDA, and inflammatory cytokines TNF-α, IL-6 and IL-1β production in kidney tissues. Meanwhile, Western blot analysis showed that alpinetin suppressed LPS-induced TLR4 expression and NF-κB activation in kidney tissues. In addition, alpinetin was found to up-regulate the expression of Nrf2 and HO-1 in a dose-dependent manner. In conclusion, alpinetin protected LPS-induced kidney injury through activating Nrf2 and inhibiting TLR4 expression. Copyright © 2015 Elsevier B.V. All rights reserved.

    Citation

    Yi Huang, Li-shan Zhou, Li Yan, Juan Ren, Dai-xing Zhou, Shu-Sheng Li. Alpinetin inhibits lipopolysaccharide-induced acute kidney injury in mice. International immunopharmacology. 2015 Oct;28(2):1003-8

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 26321118

    View Full Text