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As general, the Human papillomavirus (HPV) causes the most sexually transmitted diseases. Among well categorized 80 types, the high-risk types HPV's 16 and 18 are highly involved in 70% of cervical cancer. The virulence of HPV is mainly exhibited by E5, E6 and E7 encoded oncoproteins that cause low to high-grade cervical lesions (CIN-1, 2, 3), leading to form 99.7% of squamous cell and 89% of adenocarcinomas cervical cancer worldwide. This study mainly encircles the major role of E5, E6 and E7 oncoproteins in HPV 16 and 18. Further discussed the uprising of significant biomarkers and their cellular process in different stages of cervical cancer with current prevention and treatment regimens. Hence, this integration will evoke novel markers, potential vaccination and various treatments approaches with special reference for HPV16 and 18 infected cervical cancers. Copyright © 2015 Elsevier Masson SAS. All rights reserved.


Sabitha Ramakrishnan, Steena Partricia, Ganeshan Mathan. Overview of high-risk HPV's 16 and 18 infected cervical cancer: pathogenesis to prevention. Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie. 2015 Mar;70:103-10

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PMID: 25776487

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