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Hematopoietic cell transplantation (HCT) represents the most common and effective form of immunotherapy for childhood malignancies. The role of the graft-versus-leukemia effect in allogeneic HCT has been well established in childhood malignancies, but is also associated with short-term and long-term morbidity. HCT may be ineffective in some settings at obtaining control of the malignancy, and as such, cannot be used as a universal cancer immunotherapy. Novel therapies using dendritic cell vaccinations, tumor-infiltrating lymphocytes, and chimeric antigen receptor T cells are being evaluated as potential adjuvants to HCT. Copyright © 2015 Elsevier Inc. All rights reserved.

Citation

Kanwaldeep Mallhi, Lawrence G Lum, Kirk R Schultz, Maxim Yankelevich. Hematopoietic cell transplantation and cellular therapeutics in the treatment of childhood malignancies. Pediatric clinics of North America. 2015 Feb;62(1):257-73

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PMID: 25435122

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