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Several lines of evidence suggest that pertussis disease will continue to rise in countries which have switched to acellular vaccines. While maternal vaccination is promising as a mitigating strategy it is unlikely to replace the need for a better vaccine. In the absence of a clear alternative, a return to using whole cell vaccines, at least in part, should not be dismissed as an option without contemporary studies of feasibility and acceptability.

Citation

Thomas L Snelling, Claire S Waddington. Whither pertussis? Expert review of anti-infective therapy. 2015 Feb;13(2):145-8

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PMID: 25426699

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