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Lead on! In the course of screening flavonoid and resveratrol libraries, abyssinone II, a naturally occurring prenylated flavonoid, was found to exhibit relatively good antitubercular and antibacterial activity. Preliminary mechanistic studies revealed that abyssinone II hyperpolarizes the bacterial membrane potential and inhibits the biosynthesis of key cellular macromolecules (DNA, RNA, and protein). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Dianqing Sun, Julian G Hurdle, Robin Lee, Richard Lee, Mark Cushman, John M Pezzuto. Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead. ChemMedChem. 2012 Sep;7(9):1541-5

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PMID: 22847956

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