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The best therapeutic effect in the treatment of patients with chronic hepatitis B was observed with the use of cycloferon in the scheme of the antiviral therapy. The combination of cycloferon with lamivudine provided complete stable remission in 54.1% of the patients, whereas the use of a-interferon in combination with cycloferon provided remission in 44.1% of the lamivudine-resistant patients. The use of cycloferon in the therapy of chronic hepatitis B made it possible to lower the frequency and manifestation level of the side effects and prevented the lamivudine resistance development and generation of the virus mutants.


T V Sologub, A A Shul'diakov, L G Goriacheva, I P Baranova, Iu N Lin'kova, A L Kovalenko, M G Romantsov. Cycloferon efficacy of therapy of chronic hepatitis B (results of randomized multicentre study)]. Antibiotiki i khimioterapii͡a = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoĭ i mikrobiologicheskoĭ promyshlennosti SSSR. 2010;55(9-10):37-41

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PMID: 21400753

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