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We developed a novel biosensor comprising a transducer of carboxyl end-capped overoxidized polypyrrole nanowire electrode and a probe of tripeptide (Gly-Gly-His) selectively cognitive of Cu2+. The developed sensor was demonstrated to specifically detect Cu2+ in the nanomolar range. The diameter of the polypyrrole nanowires, prepared by one step template-free polymerization, was approximately 60-90 nm. For functionalization of the electrode, the carboxyl group was introduced by the addition of pyrrole-α-carboxylic acid which was covalently coupled with the amine group of the tripeptide. The structural features of the peptide functionalized nanowire electrode were confirmed by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) spectroscopy. Using cyclic and square wave voltammetry, the nanowire biosensor proved to be highly sensitive to Cu2+ in the range of 20-300 nM. Copyright © 2010 Elsevier B.V. All rights reserved.


Meng Lin, Misuk Cho, Woo-Seok Choe, Ji-Beom Yoo, Youngkwan Lee. Polypyrrole nanowire modified with Gly-Gly-His tripeptide for electrochemical detection of copper ion. Biosensors & bioelectronics. 2010 Oct 15;26(2):940-5

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PMID: 20630738

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