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Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.

Matthew P Strout, David G Schatz

Yale Cancer Center, Department of Internal Medicine, Section of Hematology, Yale University School of Medicine, New Haven, CT 06520, USA.

Cancer cell 2009 Sep 8


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  • activation induced deaminase
  • blast crisis
  • chronic myeloid leukemia
  • drug resistance
  • imatinib
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    Very little is known about how acquired oncogenic mutations arise. In this issue of Cancer Cell, Klemm and colleagues present evidence supporting a role for the antibody diversification enzyme activation-induced deaminase (AID) in the generation of mutations associated with disease progression and drug resistance in chronic myeloid leukemia.

    Citation

    Matthew P Strout, David G Schatz. Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way. Cancer cell. 2009 Sep 8;16(3): 174-6

    PMID: 19732715

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