NextBio

TMPRSS2-ERG and PTEN loss in prostate cancer.

Jeremy A Squire

Nature genetics 2009 May


filter terms:
  • humans
  • mouse
  • prostate cancer
  • PTEN
  • TMPRSS2
    • Sizes of these terms reflect their relevance to your search.

    Two studies show that the common recurrent gene fusion between TMPRSS2 and ERG promotes prostate cancer in both mouse and humans when PTEN is concurrently lost. In human prostate cancer, the presence of both these aberrations may be indicative of poor prognosis, suggesting that preclinical therapeutic research should target both of these pathways.

    Citation

    Jeremy A Squire. TMPRSS2-ERG and PTEN loss in prostate cancer. Nature genetics. 2009 May;41(5): 509-10

    PMID: 19399032

    View Full Text

    © 2009 NextBio