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Endothelial cells form a phalanx to block tumor metastasis.

Victoria L Bautch

Cell 2009 Mar 6


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  • blood vessels
  • endothelial cell
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    Tumor blood vessels deliver oxygen poorly, thereby contributing to tumor hypoxia and upregulation of proangiogenic cytokines in an escalating feedback loop. Mazzone et al. (2009) now show that reducing the amount of a protein involved in endothelial oxygen sensing leads to changes in endothelial cell shape that interrupt this feedback loop and reduce tumor metastasis.

    Citation

    Victoria L Bautch. Endothelial cells form a phalanx to block tumor metastasis. Cell. 2009 Mar 6;136(5): 810-2

    PMID: 19269358

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