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Four additional new bioactive heptenes, melodorinol [2], homomelodienone [4], 7-hydroxy-6-hydromelodienone [5], and homoisomelodienone [7] have been isolated from Melodorum fruticosum. These compounds were slightly to significantly cytotoxic to human tumor cell lines. Their structures have been determined by comparison of their 1H-nmr, 13C-nmr, and mass spectral data with those of prototype compounds (acetylmelodorinol [1], melodienone 3, and isomelodienone [6]).


J H Jung, C J Chang, D L Smith, J L McLaughlin, S Pummangura, C Chaichantipyuth, C Patarapanich. Additional bioactive heptenes from Melodorum fruticosum. Journal of natural products. 1991 Mar-Apr;54(2):500-5

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PMID: 1919592

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