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Klinefelter syndrome (KS) is the most common chromosomal abnormality in humans. Taurodontism may occur as one of many dentofacial manifestations of KS and can be detected before development of other physical characteristics. Identification of patients with taurodontic teeth may lead to early recognition of the disorder and could substantially improve quality of life. The objective of this report is to review the general characteristics and dentofacial manifestations of KS, specifically taurodontism, and present a patient with the 48,XXXY variant where root-canal therapy was successfully completed in 3 anatomically varied taurodontic teeth.


Michael Joseph. Endodontic treatment in three taurodontic teeth associated with 48,XXXY Klinefelter syndrome: a review and case report. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2008 May;105(5):670-7

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PMID: 18442747

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