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Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac-1-(3-trifluoromethylphenyl)propan-2-ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine. Copyright 2002 Wiley-Liss, Inc.


Nicola D'Antona, Sebastiano Mangiafico, Giovanni Nicolosi. Effective enzymatic resolution of rac-1-(3-trifluoromethylphenyl)propan-2-ol, precursor of fenfluramine. Chirality. 2002 May 5;14(4):325-8

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PMID: 11968073

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