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Regiospecific synthesis of title compounds is based either on cycloaddition of ketene acetals derived from Hagemann's ester or of homophthalic anhydrides. Thus, tetracenomycin D and 3,8-di-O-methyl saintopin have been prepared in few steps. New derivatives of 10-deoxysaintopin have been also obtained. Evaluation of their cytotoxicity against L1210 leukemia cells are reported.


Philippe Martin, Stéphane Rodier, Martine Mondon, Brigitte Renoux, Bruno Pfeiffer, Pierre Renard, Alain Pierré, Jean Pierre Gesson. Synthesis and cytotoxic activity of tetracenomycin D and of saintopin analogues. Bioorganic & medicinal chemistry. 2002 Feb;10(2):253-60

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PMID: 11741773

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