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Bryan Dickinson
Graduate Student, UC Berkeley
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Graduate Student, UC Berkeley, Berkeley, California, United States
education
BS, Biochemistry, University of Maryland at College Park, College Park, Maryland, United States
Aug 2002-Dec 2005
research summary
Developing targeted fluorescent sensors for hydrogen peroxide and their application to cell culture fluorescent microscopy. Specifically, deducing the biological effects of hydrogen peroxide on both healthy and diseased signaling pathways.
publications
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We report the synthesis, properties, and cellular application of Naphtho-Peroxyfluor-1 (NPF1), a new fluorescent indicator for hydrogen peroxide based on a red-emitting naphthofluorescein platform. Owing to its boronate cages, NPF1 features high selectivit…
Bioorganic & medicinal chemistry letters. 2008 Nov 15
We present the design, synthesis, and biological applications of mitochondria peroxy yellow 1 (MitoPY1), a new type of bifunctional fluorescent probe for imaging hydrogen peroxide levels within the mitochondria of living cells. MitoPY1 combines a chemosele…
Journal of the American Chemical Society. 2008 Jul 30
In solution, Lys48-linked di-ubiquitin exists in dynamic equilibrium between closed and open conformations. To understand the effect of interdomain motion in polyubiquitin chains on their ability to bind ligands, we cyclized di-ubiquitin by cross-linking t…
Protein science : a publication of the Protein Society. 2007 Mar
